Antiphlogistic


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Related to Antiphlogistic: cytophylactic, cicatrisant

Antiphlogistic

 

a medicinal preparation that suppresses inflammatory reactions. Antiphlogistics include derivatives of salicylic acid, such as sodium salicylate, salicylamide, and acetylsalicylic acid, and derivatives of pyrazolone, such as amidopyrine, analgin, and butadion. Indomethacin, a derivative of indole, is also an antiphlogistic.

Antiphlogistics are used for treating rheumatism, neuritis, myositis, arthritis, and other diseases that are accompanied by inflammation. An intense antiphlogistic effect is exerted by the hormones of the adrenal cortex, or corticosteroids, which include cortisone and hydrocortisone. Adrenocortical synthetic preparations include prednisolone, dexamethasone, and Synalar. With local use, an antiphlogistic effect is produced by substances that constrict blood vessels, such as adrenaline, ephedrine, and naphthyzine. Astringents and coating agents are also antiphlogistic.

REFERENCES

Anichkov, S. V., and M. L. Belen’kii. Uchebnik farmakologii, 2nd ed. Leningrad, 1968.
Mashkovskii, M. D. Lekarstvennye sredstva, 7th ed., parts 1‣2. Moscow, 1972.
Sigidin, Ia. A. Mekhanizmy lechebnogo deistviia antirevmaticheskikh sredstv. Moscow, 1972.
References in periodicals archive ?
Considering its high anti-inflammatory activity, maytenoic acid plays a primary role in the antiphlogistic effect of the whole chloroform extract of M.
Taking into account the low risk of side effects and the further beneficial therapeutical effects like spasmolytic and antiphlogistic activity, yarrow preparations might be appropriate especially for long-term treatment of digestive disorders.
The in vivo antiphlogistic activity of these compounds was attributed to different actions, such as inhibition of histamine release, arachidonic acid metabolism, elastase activity, complement system, as well as nitric oxide production (Kapil and Sharma, 1995; Liu, 1995; Ringbom et al.
In particular, Coptidis Rhizoma, a natural herb containing high levels of berberine, is used widely as a therapeutic agent for gastrointestinal disorders, and infectious and/or inflammatory diseases, because of its antiphlogistic, sedative, antidotal, hemostatic, and stomachic activity (Fujimura et al.
In case of Harpagophytum extracts, it is widely accepted that harpagoside is the major active constituent being responsible for the analgetic and antiphlogistic potential, since in vitro studies in human whole blood showed that the inhibition of the biosynthesis of cysteinyl-leukotrienes strongly depended on the harpagoside content, whereas extract fractions without harpagoside had no effects (Loew et al.
Use of granuloma pouch technique in the study of antiphlogistic corticoids.
Salix extracts have demonstrated analgesic, antiphlogistic and antipyretic effects in various animal models (ESCOP, 1997; Leslie, 1978; Loniewski et al.
Leguminosae used to release spasmolytic symptoms and as an antitussive, antiphlogistic, and antitoxicant 9.
It is also well known as an antidote, an antiphlogistic and a cure for gastrointestinal disorders.