Antipyretics


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Related to Antipyretics: Paracetamol, aspirin, Antibiotics

Antipyretics

 

pharmacological substances of various chemical structures that have a fever-reducing, analgesic (pain-relieving), and anti-inflammatory effect. Antipyretics include derivatives of salicylic acid (sodium salicylate, acetylsalicylic acid, salicylamide, and methyl salicylate), pyrazolone (antipyrine, aminopyrine, Analgin, and Butadion), and aniline (phenacetin and acetaminopen). Antipyretics are often combined with each other or with caffeine to strengthen their pharmacological effect. The most widely used combinations are Analgin + aminopyrine + caffeine; askofen + acetylsalicylic acid + phenacetin + caffeine; tsitramon + acetylsalicylic acid + phenacetin + caffeine + cacao + citric acid + sugar; and pirafen (aminopyrine + phenacetin). The combined preparation reopirin (Butadion + aminopyrine) is produced in Hungary;piranal (aminopyrine + Analgin) and sedalgin (codeine + caffeine + phenacetin + acetylsalicylic acid + phenobarbital) are produced in Bulgaria.

The antipyretic effect of these substances is observed if they are administered to an organism that is suffering from fever; at normal body temperatures there is no lowering of temperature. The antipyretic effect is explained by the selective action of the antipyretics on the heat-regulation centers of the body; increased heat loss occurs, which is caused by the dilation of the skin blood vessels, increased secretion of the sweat glands, and acceleration of respiration. The analgesic effect of antipyretics is not completely understood; it is thought that they act on the pain centers of the brain. The anti-inflammatory properties of the salicylates are associated with their stimulating effect on the pituitary and an increase in the secretion of adrenocorticotropic hormone (ACTH). They decrease the activity of the enzyme hyaluronidase and lower the permeability of the capillaries. These properties of antipyretics determine their therapeutic use for headaches, neuralgia, and muscle and joint pains, as well as their use as anti-inflammatory agents for acute rheumatic fever, non-rheumatoid arthritis, and exudative pleurisy.

Antipyretics are usually taken internally, but methyl salicylate is applied externally (for rubdowns), according to a doctor’s instructions. Complications may arise during prolonged use of antipyretics. The side effects of salicylic acid derivatives include nausea, vomiting, noise in the ears, irritation, and sometimes ulceration of the mucous lining of the stomach; the derivatives of pyrazolone may suppress leuko-poiesis and cause agranulocytosis, and aniline derivatives may cause the formation of methemoglobin. As a rule, all of these complications disappear after the medication is discontinued.

REFERENCES

Zakusov, V. V. Farmakologiia, 2nd ed. Moscow, 1966.
Mashkovskii, M. D. Lekarstvennye sredstva, 6th ed., vols. 1–2. Moscow, 1967.

IU. V. BUROV

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The effect on mortality of antipyretics in the treatment of influenza infection: systematic review and meta-analysis.
In the study it was noticed that the classes of drugs that were commonly used were antipyretics (78%), analgesics (72%), antihistamines (42%) and antibiotics (38%).
Although fever was considered a protective response for thousands of years the advent of antipyretic drugs has led to the common belief that fever is maladaptive and harmful3 and can cause brain damage and death.
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Alternating antipyretics for fever reduction in children: an unfounded practice passed down to parents from pediatricians.
The aim of this study was to investigate if the antipyretics (paracetamol and ibuprophen) given to the patients who referred to Hacettepe University ?
Although alternating or combining antipyretics is common, "questions remain regarding the safety of this practice as well as the effectiveness in treating discomfort, which is the primary end point," according to the report.
Alternating antipyretics: Antipyretic efficacy of acetaminophen versus acetaminophen alternated with ibuprofen in children.
Antipyretics don't appear to affect the recurrence of febrile seizures.