Antispasmodic

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antispasmodic

[¦an·tē‚spaz′mäd·ik]
(pharmacology)
An agent, such as benzyl benzoate, that relieves convulsions and the pain of muscular spasms.

Antispasmodic

 

one of a group of pharmacological substances with various chemical structures that induce the relaxation of the smooth muscles of, for example, the blood vessels, bronchi, and gastrointestinal, biliary, and urinary tracts.

Antispasmodics may be, according to their mechanism of action, neurotropic or musculotropic. Neurotropic agents include cholinolytics, for example, such m-cholinolytics as atropine, spasmolytin, thiphen, aprophen, and diprophen. Conventionally, they also include sympathomimetics (Adrenalin, ephedrine, Is-adrine [Aleudrin]), which relax the smooth muscles of the bronchi, intestines, and other organs by exciting sympathetic nerves. Musculotropic antispasmodics, including papaverine and drotav-erinum, directly act on the smooth muscles.

Antispasmodics are used to treat many diseases accompanied by the intensified contraction of the smooth muscles, including asthma, renal colic, and spasms of the cerebral blood vessels.

REFERENCES

Kuznetsov, S. G., and S. N. Golikov. Sinteticheskie alropinopodobnye veshchestva. Leningrad, 1962. (Bibliography.)
Wesselius de Casparis, A. “Neurotropic Versus Musculotropic Antispasmodics.” Medicamundi, 1962, vol. 8, no. 5, pp. 92–98. (Bibliography.)

V. V. ZAKUSOV

References in periodicals archive ?
A total of 35 trials were included in this review: 9 trials compared fibre with either a placebo or no treatment, 19 trials compared antispasmodics with placebo, 4 trials compared peppermint oil with placebo, and 3 trials compared both fibre and antispasmodics with placebo.
Primary outcomes for this review were the efficacy of fibre, antispasmodics and peppermint oil in reducing or curing either global symptoms or abdominal pain associated with IBS.
Overall, 39% of participants taking antispasmodics had persistent symptoms after treatment compared with 56% taking the placebo.
This systematic review and meta-analysis shows that ispaghula husk, antispasmodics (particularly hyoscine), and peppermint oil are all effective treatments for irritable bowel syndrome.
The tablets contain the ingredient hyoscine N-butylbromide, an antispasmodic used to relieve colicky abdominal pain that is caused by painful spasms in the muscles of the gastrointestinal tract.
The researchers further analysed 22 studies comparing various antispasmodics with placebo in 1778 patients.
Buscopan(R) is the leading global over the counter antispasmodic brand that provides reliable relief from the pain and discomfort due to abdominal cramps.
Other contributing factors include side effects from medication, particularly pain medications, antidepressants, antacids, antispasmodics and blood pressure medications.
Prosed EC is the same classic combination as Prosed/DS containing an analgesic, antispasmodics, and antiseptics with the addition of enteric coating which minimizes gastric upset.
Current therapies, ranging from dietary changes to over-the-counter medicines and prescription antispasmodics, provide limited or erratic treatment response.
Current therapies include dietary changes, over-the-counter laxatives, antidiarrheals, prescription antispasmodics and gastroprokinetics that provide limited or erratic treatment response.
Through the new Generic Development and Manufacturing Group, Apothecon seeks to expand into such product areas as psychotherapeutics, analgesics, antiarthritics, antispasmodics, hormones and cholesterol-lowering agents.