Antispasmodic

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antispasmodic

[¦an·tē‚spaz′mäd·ik]
(pharmacology)
An agent, such as benzyl benzoate, that relieves convulsions and the pain of muscular spasms.

Antispasmodic

 

one of a group of pharmacological substances with various chemical structures that induce the relaxation of the smooth muscles of, for example, the blood vessels, bronchi, and gastrointestinal, biliary, and urinary tracts.

Antispasmodics may be, according to their mechanism of action, neurotropic or musculotropic. Neurotropic agents include cholinolytics, for example, such m-cholinolytics as atropine, spasmolytin, thiphen, aprophen, and diprophen. Conventionally, they also include sympathomimetics (Adrenalin, ephedrine, Is-adrine [Aleudrin]), which relax the smooth muscles of the bronchi, intestines, and other organs by exciting sympathetic nerves. Musculotropic antispasmodics, including papaverine and drotav-erinum, directly act on the smooth muscles.

Antispasmodics are used to treat many diseases accompanied by the intensified contraction of the smooth muscles, including asthma, renal colic, and spasms of the cerebral blood vessels.

REFERENCES

Kuznetsov, S. G., and S. N. Golikov. Sinteticheskie alropinopodobnye veshchestva. Leningrad, 1962. (Bibliography.)
Wesselius de Casparis, A. “Neurotropic Versus Musculotropic Antispasmodics.” Medicamundi, 1962, vol. 8, no. 5, pp. 92–98. (Bibliography.)

V. V. ZAKUSOV

References in periodicals archive ?
Overall, the available data suggest that exposure to an antispasmodic in pregnancy is low risk for embryo, fetal, and newborn harm.
1) The pooled results from 13 RCTs with 1392 patients (65% female, mean age 45 years) showed that more patients had improved abdominal pain with antispasmodics than placebo over treatment periods varying from 6 days to 6 months (58% vs 46%; relative risk [RR]=1.
Trials included in the review needed to compare fibre, antispasmodics or peppermint oil with a placebo or no treatment.
About 54 per cent of patients put on to a high bran diet had unimproved symptoms, while 39 per cent treated with antispasmodics had unimproved symptoms after treatment.
The research team led by Dr Alex Ford performed a systematic review and meta-analysis of randomised trials comparing fibre, antispasmodics and peppermint oil with placebo or no treatment in more than 2500 adult patients with IBS, reports the British Medical Journal.
It is an antispasmodic that contains substances that promote GI smooth-muscle relaxation.
His hip was literally dislocating because of the spasticity, and he was taking so many antispasmodics that his memory was failing.
In terms of the medications being used, reports show that more than two-thirds of retail pharmacy sales last year were in just 10 therapeutic classes, with psychotherapeutic drugs, cardiovascular therapies and antispasmodics atop the list.
manufactures urinary analgesics, antispasmodics, and antiseptics along with a line of suppositories.
Many patients do not need antispasmodics or diarrhea medications.