Typically, these methods measure both apo B-100
and apo B-48, but in fasting samples greater than 95% of apo Bin plasma is apo B-100
and almost all of it is associated with LDL (6).
Binding of LDLs to the LDLR is mediated by interactions between the LDLR and the Apo B-100
The primary endpoint is the reduction in Apo B-100
, the atherogenic lipoprotein in LDL (low-density lipoprotein), compared to placebo.
We aimed to investigate the frequency of apo B-100
mutations (colon 3500) C9774T (Arg 3500 [right arrow] Trp) and G9775A (Arg 3500 [right arrow] Gln) in patients with atherosclerosis in comparison with healthy subjects.
30] Measuring apo B-100
and LDL-C concentrations in serum or plasma may be employed for CHD risk stratification.
5 are cleared from the plasma mostly by the kidney, whereas truncated apo B molecules with a size [greater than or equal to] 70% of that of apo B-100
are removed by the liver (1,2).
Preclinical and clinical testing of MBX-8025 indicates that the drug has the potential to improve a number of lipid parameters that are abnormal in different types of dyslipidemia, including high LDL (or "bad") cholesterol, high Apo B-100
(the atherogenic lipoprotein), low HDL (or "good") cholesterol and high triglycerides (fats).
We used the monoclonal antibody 4E6, which is directed specifically against an epitope in the apolipoprotein B-100 (apo B-100
) moiety of oxLDL that is formed from the substitution of aldehydes for lysine residues in apo B-100
He and his associates were the first to achieve complete synthesis of a plasma apolipoprotein (apo C-I); they also determined the complete cDNA and amino acid sequence of apo B-100
, one of the largest proteins ever sequenced and a key protein in atherosclerosis.
is essential for the binding of LDL particles to the LDL receptor (LDLR) for cellular uptake and degradation (2).
Gotto and his associates were the first to achieve the complete synthesis of a plasma apolipoprotein (apo C-I), and they also determined the complete cDNA and amino acid sequence of apo B-100
, one of the largest proteins ever sequenced and a key protein in atherosclerosis and cardiovascular disease.
Turbidity is a source of interference in apo B immunoassays of lipemic samples, and cross-reactivity of apo B-100
antibodies with apo B-48 on chylomicrons can also produce interference.