apoptosis

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apoptosis

[‚ā·pō′tō·səs]
(cell and molecular biology)
Death of cells triggered by extracellular signals or genetically programmed events, carried out by processes within the cell, and characterized by systemic breakdown of cellular constituents, in particular chromosomal deoxyribonucleic acid; may be involved in normal development and aging, or may serve to eliminate defective or damaged cells. Also known as programmed cell death.
References in periodicals archive ?
The present results suggest that, because the maternal circulation is higher in oxygen concentration than fetal circulation, the oxygen environment of maternal circulation induces apoptotic changes in fetal NRBCs transferred to maternal circulation, leading to clearance of NRBCs from the maternal circulation.
1,2) It remains unclear why such cancer cells continue to proliferate rather than become apoptotic.
Compound Strategies at Work: Competitive Benchmarking of Apoptotic Drugs in Oncology by Compound Type (7 Different Compound Strategies)
In general terms, apoptotic pathways can be sub-divided into two categories, the extrinsic pathway and the intrinsic pathway (Wajant, 2002).
At least 10,000 cells were subjected to flow cytometry (Becton-Dickinson Biosciences, Drive Franklin Lakes, USA) to identify viable, apoptotic, and necrotic populations.
As has been highlighted earlier, while the extrinsic apoptotic pathway plays a role in villous atrophy in patients with celiac disease, studies on the intrinsic and common apoptotic pathways in patients with celiac disease are sparse.
Hotchkiss et al showed that both the extrinsic and intrinsic apoptotic pathways are important in the pathogenesis of sepsis (12) and that there may be communications and interactions between the two apoptotic pathways mediated by the truncated form of BH3, produced by caspase-8 mediated BID cleavage.
Using the D-Pop kit, apoptotic bodies and potentially other large particles are captured from biological fluids by passing them through a filter in a syringe format.
As shown in Figure 2, the proliferation index and apoptotic rate of mammary cells (Figure 3) were lower under high temperature conditions than those under normal temperature conditions, and their changing tendencies were different between the high and normal temperatures.
A group of researchers in biochemistry, cancer research,gastroenterology, and other scientific fields in Europe, the US, Asia, and Iran address apoptotic cell signaling pathways in health and disease; natural compounds as regulators of cancer cell signaling pathways; natural compounds regulating the cell cycle, cell signaling pathways, and as inhibitors of inflammation; dietary agents in health and disease; MAP kinase signaling pathways; neuroprotection; reactive oxygen species; and other types of cell death.
Finally, when the authors assessed the relationship between EBV expression and apoptotic proteins, they found that in Indian children with HL EBV was significantly associated with lower expression levels of the anti-apoptotic protein bak (1).

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