BCR-ABL maintains resistance of chronic myelogenous leukemia cells to apoptotic cell death
These findings provide hope that apoptotic cell death
in plague may be preventable by a Bcl-2-based therapy.
We now understand a fair amount about apoptotic cell death
Apoptotic cell death
occurs during a variety of physiological processes, including normal development, differentiation, and embryogenesis.
Although the observation of necrotic cells in such situations complicates the issue, and indeed, is a subject beyond the scope of this article, it is now becoming generally accepted that apoptotic cell death
is an early and important event in ischemia/reperfusion-related tissue and organ damage.
Birinapant (formerly TL32711) is a small molecule peptidomimetic of Smac (Second mitochondrial-derived activator of caspases), an endogenous regulator of apoptotic cell death
that selectively antagonizes multiple Inhibitor of Apoptosis Proteins (IAPs).
Flow cytometry showed that stimulation with Saxi A induced apoptotic cell death
in a concentration-dependent manner in both cell lines (Fig.
When combined with various nucleoside analogues clinically used in AML therapy such as Ara-C, clofarabine, and demethylating agents decitabine and 5-azacytidine, TL32711 synergistically enhanced apoptotic cell death
in AML cells and AML stem/progenitor cells.
4 mg/mL, in concert with induction of apoptotic cell death
A review article focusing on induced disturbances of calcium homeostasis, genomic damage, and apoptotic cell death
caused by arsenic and its organic metabolites appears in the June 2005 issue of EHP.
Genetic factors have been identified that cause apoptotic cell death
and markers for apoptosis continue to be discovered.
While standard therapy typically induces apoptotic cell death
, MTI-101 targets alternative cell death pathways critical for the treatment of refractory disease.