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Astrocytes maintain high intracellular concentrations of certain antioxidants, such as vitamins E and C and antioxidant enzymes, which play a major neuroprotective role in brain resistance to the deleterious effects of superoxides (Lotharius et al.
133 CONVERTING PATIENT FIBROBLASTS TO MOEL ASTROCYTE TOXICITY IN FAMILIAL AND SPORADIC ALS
The researchers have developed new analysis methods to evaluate neurotransmitter concentrations in the brains of normal and genetically modified mouse models for Alzheimer's disease (AD mice) and their study of AD mice shows that the high concentration of the GABA neurotransmitter in the reactive astrocytes of the dentate gyrus correlates with the animals' poor performance on tests of learning and memory.
In the next section, we discuss how brain endothelial cells and astrocytes contribute to the formation of metastases in the CNS and review the evidence implicating endothelial cells and astrocytes in therapeutic resistance.
Clinical aspects and pathology of Alexander disease, and morphological and functional alteration of astrocytes induced by GFAP mutation.
The latest study, from the Tuft University School of Medicine and the Children''s Hospital of Philadelphia, provides the strongest evidence yet that a cell called an astrocyte is the culprit.
Vimentin-IR astrocytes of the optic chiasm present a well-ramified filamentous shape resembling to a well-organised network (Fig.
Three forms of astrocytes exist in the central nervous system: fibrous, protoplasmic and plasmatofibrous.
The prodrug mechanism of AV-101 supports critical functions of astrocyte (the most numerous non-neuronal brain cells), by delivering a significantly more potent and selective chemical variant of KYNA, a key regulator of NMDAR that is normally produced by astrocytes in the brain.
Glia come in three varieties: microglia, astrocytes and oligodendrocytes.
Recent studies suggest that astrocytes (the most abundant cells of the brain) actively participate in the modulation of physiological and circadian behavioral processes in invertebrates.
Aquaporins (AQP) and astrocytes were examined to elucidate the participation of these water channel proteins and glial cells in the pathophysiology and resolution of hydrocephalus.
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- Astrocyte-derived trophic factor
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