Hershko, Avram

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Hershko, Avram,

1937–, Israeli biochemist, M.D. Hebrew Univ.–Hadassah Medical School, Jerusalem, 1965, Ph.D. 1969. Hershko has been a professor at the Rappaport Faculty of Medicine at the Technion (Israel Institute of Technology), Haifa, since 1972. In 2004 he received the Nobel Prize in Chemistry with Aaron CiechanoverCiechanover, Aaron,
1947–, Israeli biochemist, M.D. Hebrew Univ.–Hadassah Medical School, Jerusalem, 1974; D.Sc. Technion (Israel Institute of Technology), Haifa, 1982. He has been on the faculty at the Technion since 1986.
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 and Irwin RoseRose, Irwin,
1926–2015, American biochemist, b. Brooklyn, N.Y., Ph.D. Univ. of Chicago, 1952. Rose was on the faculty of Yale Medical School from 1954 to 1963 and a senior member of the Fox Chase Cancer Center in Philadelphia from 1963 until 1995.
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 for discovering the mechanism underlying protein degradation. Their work resulted in a molecular-level understanding of how cells control such processes as DNA repair, cell division, and immune functions by breaking down selected proteins using a regulatory tag called ubiquitin. This knowledge has helped in the fight against cystic fibrosis, cervical cancer, and other diseases that occur when the degradation process is flawed.
References in periodicals archive ?
Contudo, a sua relacao com a proteolise so viria a ser publicada no trabalho do professor/pesquisador Avram Hershko, na decada de 1980, que culminaria no premio Nobel de quimica em 2004.
Technion Professors Avram Hershko and Aaron Ciechanover, whose research has been funded by ICRF for 22 years, received the 2004 Nobel Prize in chemistry for discovering a process that lets cells destroy unwanted proteins--the ubiquitin system.
The Royal Swedish Academy of Sciences chose Irwin Rose, 78, of the University of California, Irvine, and Avram Hershko, 67, and Aaron Ciechanover, 57, both of the Israel Institute of Technology, in Halla, Israel, "for the discovery of ubiquitin-mediated protein degradation.
En la decada de 1980, los bioquimicos israelies Aaron Ciechanove y Avram Hershko y el bioquimico estadunidense Irwin Rose investigaron el proceso por el cual las celulas identifican y seleccionan a las proteinas defectuosas para destruirlas y preservar el buen funcionamiento del organismo.
Aaron Ciechanever, 57, and Avram Hershko, 67, of the Technion-Israel Institute of Technology in Haifa and Irwin Rose, 78, of the University of California, Irvine will share the roughly $1.
Ferber studied biochemistry at the Technion-Israel institute of Technology, under the supervision of Professor Avram Hershko and Professor Aharon Ciechanover, winners of the Nobel Prize in Chemistry in 2004.
Aaron Ciechanover and Avram Hershko of the Technion-Israel Institute of Technology in Haifa and Irwin Rose of the University of California, Irvine will share the prize, which was announced at press time.
Aaron Ciechanover, Avram Hershko and Irwin Rose for discovering and characterizing the ubiquitin pathways, which play fundamental roles in human health and disease with many human pathologies been linked to changes in ubiquitin pathway enzymes.
Aaron Ciechanover is now a Technion Distinguished Research Professor in the Rappaport Faculty of Medicine Research Institute at the Technion in Haifa, shared the Nobel Prize "for the discovery of ubiquitin-mediated protein degradation" jointly with his graduate studies mentor Avram Hershko, MD, PhD, and Irwin Rose, PhD.
Avram Hershko and Aaron Ciechanover - the 2004 Nobel Prize in chemistry laureates for the discovery of the ubiquitin system - constitutes the company's scientific advisory board.
Nobel prize content by Nobel prize winners: The essential role of protein degradation as a regulatory switch in cell physiology has been honoured by the 2004 Nobel prize in Chemistry to Aaron Ciechanover, editor of the series, and Avram Hershko, the author of the opening chapter of volume 1.
Avram Hershko and Aaron Ciechanover, who were awarded the 2004 Nobel Prize in chemistry for their discovery of the ubiquitin system, lead the company's scientific advisory board.