azole

(redirected from Azoles)
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Related to Azoles: Allylamines

azole

[′ā‚zōl]
(organic chemistry)
One of a class of organic compounds with a five-membered N-heterocycle containing two double bonds; an example is 1,2,4-triazole.
References in periodicals archive ?
fumigatus susceptibility testing in clinical settings, the frequency with which clinicians request susceptibility testing, and the degree to which clinicians have observed azole resistance.
Physicians can use pharmacokinetic profiles to choose among different statins and azoles to help avoid a drug interaction (table 26'71019).
Some studies have attributed resistance in Aspergillus partially to use of azole antifungal agents in agriculture.
Although this inverse relationship has been previously reported, (5,7,27,28) targeted deletion of ERG3 or ERG11 in Candida albicans and Candida glabrata seems to be a potential mechanism that may lead to increased susceptibility to AMB with increased resistance to azoles.
In a further analysis that controlled for confounding by underlying disease (vaginal candidiasis), pregnancies exposed to oral fluconazole were at significantly higher risk of spontaneous abortion, compared with pregnancies exposed to topical azoles (HR, 1.
In addition, the patients informed if they had been previously exposed to azoles at least once in the last year as treatment for VVC.
Among the azoles, the highest susceptibility was seen towards fluconazole followed by voriconazole and the least was towards ketoconazole.
Se observo una buena tolerancia a azoles y respuesta clinica.
In such cases, an azole cream is the better treatment choice, because azoles will kill Candida, bacteria, and dermatophytes that are there, she said.
This volume contains 13 chapters on antifungal research from a molecular and genomic perspective, discussing the molecular mechanisms responsible for antifungal resistance to the classical molecules, azoles, polyenes, and echinocandins; fungal biofilms; fungal-specific biological pathways that constitute potential new targets; drug combinations as a strategy to potentiate existing antifungal agents; strategies for the identification of the mode of action of antifungal drug candidates; the impact of high-throughput screenings of chemical compound collections; modulating the host response; antifungal vaccines and immunotherapeutics; and animal models.
Short-term therapy of up to 3 days with local azoles is recommended and the symptoms usually disappear after 2 to 3 days.
A review of randomised control studies found allylamines were effective in curing fungal infections and produced a faster response than azoles but cure rates were similar.