It is intended for women with heavily pretreated ovarian cancer that is associated with defective BRCA genes
Audeh said at least seven other PARP inhibitors are in development and testing for cancers associated with BRCA gene
mutations, and for others that may stem from similar mutations.
But while competitors now have more flexibility to devise tests that compete with Myriad's, the exclusion for complementary DNA means that Myriad retains much of its patent strength around the two BRCA genes
Myriad's patent-authorized monopoly on BRCA gene
testing may have ended, but its legacy will continue.
Mrs Duncan, who is married to Graeme, 43, a civil engineer, said: "It is great that research is being done into the BRCA gene
and it is extremely important that the North East is at the forefront of research.
The argument that Antonia and Julie make in favour of the pregnancy hinges on the fact the BRCA gene
could mean a premature hysterectomy for Antonia, depriving her of another chance to have a baby - like her sister, Jasmine.
In our practice, we have noticed that women with a known deleterious BRCA gene
mutation are being diagnosed earlier with the disease than their moms or aunts," notes Utton, the study's first author.
However, not all women diagnosed with breast or ovarian cancer have BRCA gene
Limited family structure and BRCA gene
mutation status in single cases of breast cancer Weitzel JN, Lagos VI, Cullinane CA et al.
Gemma Wilkie, a spokeswoman for the HFEA, said: "I can confirm that the HFEA has granted a licence to the University College Hospital in London to use PGD (pre-genetic diagnosis) to screen for the BRCA gene
which causes a susceptibility to inherited breast cancer.
Kretchmer's genetic mutation -- the BRCA gene
-- increases the chances of breast and ovarian cancer, the latter which killed her maternal grandmother.
The investigators paired women-who had had invasive breast cancer diagnosed during 1970-2001 (cases) with women who had never received a diagnosis of this cancer (controls); they matched each pair for year of birth, country of residence, BRCA gene
mutated and history of ovarian cancer.