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BRCA gene |
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BRCA gene: see breast cancer breast cancer, cancer that originates in the breast. Breast cancer is the second leading cause of cancer death in women (following lung cancer ). Even allowing for improvements in detection (i.e. ..... Click the link for more information. . How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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| Since its discovery in 1994, the BRCA1 gene has given up its secrets grudgingly. The oncogenes c-myc, c-met, k-ras and the neoplastic progression protein-3 (Npn3) were also increased 2- to 3-fold in arsenic-induced HCC and nontumorous, normal liver from arsenic exposed mice, while the tumor suppressors BRCA1 and BRCA2 decreased 30-50%. 1) In a multicenter case-control study, women with a BRCA1 mutation who were ever-users of oral contraceptives had 20% higher odds of having had breast cancer than never-users. |
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