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(ĭsŏf`əgəs), portion of the digestive tube that conducts food from the mouth to the stomach. When food is swallowed it passes from the pharynxpharynx
, area of the gastrointestinal and respiratory tracts which lies between the mouth and the esophagus. In humans, the pharynx is a cone-shaped tube about 4 1-2 in. (11.43 cm) long.
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 into the esophagus, initiating rhythmic contractions (peristalsis) of the esophageal wall, which propel the food along toward the stomach. The walls of the esophagus are lined with mucous glands that continue the lubrication of the food as it is conducted to the stomach. The human esophagus is about 10 in. (25 cm) long and 1 in. (2.5 cm) in diameter. See digestive systemdigestive system,
in the animal kingdom, a group of organs functioning in digestion and assimilation of food and elimination of wastes. Virtually all animals have a digestive system. In the vertebrates (phylum Chordata, subphylum Vertebrata) the digestive system is very complex.
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A section of the alimentary canal that is interposed between the pharynx and the stomach. Because of divergent specializations in the various vertebrates, the esophagus cannot be described in general terms and is not always distinguishable.

In humans it is a tube running the full length of the neck and the thorax, held in its position ventral to the vertebral centra by a tunica adventitia of loose connective tissue. It has an inner lining of folded mucous membrane with an exceptionally thick lamina propria, a submucosa of elastic and collagenous connective tissue, and two layers of muscle. The musculature is striated in the anterior third of its length, unstriated in the posterior third, and variably intermixed in the middle. It is supplied with autonomic nerve fibers.

Although normally collapsed, the human esophagus is capable of considerable distension during the rapid passage of swallowed material, under which condition the folds of mucous membrane and lamina propria are temporarily smoothed out. Numerous microscopic esophageal glands open into the lumen, extending their compound tubules out into the submucosa.

In humans the transition from the esophagus to the stomach occurs quite abruptly at the diaphragm. The pharynx narrows posteriorly like a funnel and the foregut may thereupon enlarge, but much of what appears to be stomach may have an esophageal character histologically. See Digestive system



the part of the alimentary canal of animals and man through which food passes. In invertebrates, the esophagus begins at the mouth opening or pharynx, extending in some animals to the beginning of the midgut or glandular stomach and in others to the masticatory stomach. In some flatworms and annelids, the esophagus is a tube connecting the pharynx to the midgut. Among mollusks, the esophagus is well developed only in gastropods and cephalopods, forming in many of these mollusks an ingluvies (crop). In arachnids and insects, the esophagus begins at the pharynx, and in crustaceans and myriapods, at the mouth opening. In higher crustaceans, king crabs, and most insects, the posterior section becomes the masticatory stomach, in which food is ground up. In echinoderms, the esophagus connects the mouth opening to the midgut; in most vertebrates, it connects the pharynx to the stomach. The length of the esophagus varies with the length of the cervical and thoracic parts of the trunk. In birds the esophagus is very long and forms the crop.

In man, the esophagus is a muscular tube about 25 cm long. It enters the abdominal cavity through the esophageal opening of the diaphragm and reaches the cardia. The esophagus narrows in three places: where it leaves the pharynx, where the trachea becomes divided into bronchi, and where the esophagus passes through the diaphragm. The walls of the esophagus consist of a layer of areolar tissue, an underlying muscular layer of external longitudinal and internal circular fibers, and a submucous layer and mucous membrane; the glands are situated in the submucous layer and the mucous membrane. The esophagus is innervated by the sympathetic, vagus, and cerebrospinal nerves. It is supplied with blood through the arterial branches of the inferior thyroid and subclavian arteries, thoracic aorta, and left gastric artery. The muscles of the esophagus contract reflexly during every swallowing movement. The contractions are in the form of waves originating in the upper part of the esophagus and extending along the entire length. The muscles arranged in rings contract successively, causing the bolus to move downward. Solid food passes through the esophagus in eight to nine sec on the average, and liquid food in one to two sec.

Diseases of the esophagus, which may be congenital or acquired, include such anomalies as atresia, congenital stenosis, and cysts; esophageal atony and paralysis; achalasia; diverticulum; hernia of the esophageal opening of the diaphragm; and esophagitis (inflammatory lesions), which may be acute, subacute, or chronic. Peptic esophagitis (reflux esophagitis) is caused by the repeated effects of active gastric juice, bile, or intestinal or pancreatic juice on the esophageal mucosa. Other esophageal irregularities include tuberculosis, syphilis, mycotic lesions, allergic and drug-induced lesions, and the presence of foreign bodies, in addition to injuries, burns, stenosis, benign and malignant tumors, and varicosity. Among the methods used to diagnose esophageal diseases are auscultation, roentgenologic and radio-isotopic examinations, esophagoscopy, biopsy and cytologic examination, and blind bougienage. Treatment, whether dietetic, medicamentous, or surgical, depends on the nature of the disease.


Vasilenko, V. Kh., A. L. Grebenev, and M. M. Sal’man. Bolezni pishchevoda. Moscow, 1971.
Gastroenterology, 2nd ed., vol. 1. Edited by H. Bockus. Philadelphia-London, 1963.


The tubular portion of the alimentary canal interposed between the pharynx and the stomach. Also known as gullet.


(US), esophagus
the part of the alimentary canal between the pharynx and the stomach; gullet
References in periodicals archive ?
Barrett esophagus develops because of chronic injury and inflammation of the esophageal epithelium due to reflux of gastroduodenal contents from gastroesophageal reflux disease.
Barrett esophagus is currently defined as the presence of IM (goblet cells) in biopsy samples obtained from an endoscopically evident mucosal abnormality in the distal esophagus.
Morphologic features are useful in distinguishing Barrett esophagus from carditis with intestinal metaplasia.
Traditionally, Barrett esophagus is considered a distinct entity from esophageal inlet patch.
Key Words: gastroesophageal reflux disease, Barrett esophagus
Complications from chronic GERD include bleeding from esophageal erosions or ulceration, stricture formation, and Barrett esophagus.
Barrett esophagus reflects replacement of squamous epithelium of the distal esophagus by glandular mucosa.
The natural history of dysplasia and cancer in esophagitis and barrett esophagus.
Barrett esophagus can be further subdivided into long-segment ([greater than or equal to] 3 cm) or short-segment (<3 cm) BE, based on the length of involvement of the distal esophagus.
Update on the diagnosis and treatment of Barrett esophagus and related neoplastic precursor lesions.
I thank Drs Al-Abbadi, Murthy, and Youngberg for their interest and kind comments regarding my recently published review article titled "Update on the Diagnosis and Treatment of Barrett Esophagus and Related Neoplastic Precursor Lesions.