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syndrome |
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syndrome Med any combination of signs and symptoms that are indicative of a particular disease or disorder syndrome [′sin‚drōm] (medicine) A group of signs and symptoms which together characterize a disease. Also known as complex. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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Mutations in the patched gene have been found to underlie the basal cell nevus syndrome in which patients develop innumerable basal cell carcinomas, as well as odontogenic jar keratocysts, craniofacial and musculoskeletal abnormalities, palmar pits, and a variety of other tumors including medulloblastomas. Discovery of the new gene is "incredibly significant in terms of understanding the pathogenesis of basal cell nevus syndrome and basal cell carcinomas in general," comments Bert Vogelstein of the Johns Hopkins Medical Institutions in Baltimore. In basal cell nevus syndrome patients, 95 percent of tumors responded. |
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