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base excision repair |
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base excision repair [′bās ek′siz·zhən ri‚per] (cell molecular) A deoxyribonucleic acid (DNA) repair system in which an altered base is removed from the sugar backbone by action of a specific DNA glycolase and then the abasic sugar is removed by apurinic/apyrimidic (AP) lyase and AP endonuclease, leaving a one-nucleotide gap that is then filled in and ligated. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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| These candidates are distributed across all the human chromosomes except for the Y-chromosome, and altogether represent > 2% of all known human genes (International Human Genome Sequencing Consortium 2004), Efforts for the EGP have also focused on completing SNP discovery across entire pathways of interacting genes, such as the base-excision repair pathway illustrated in Figure 1. |
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