Basal Membrane

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basal membrane

[′bā·səl ′mem‚brān]
The tissue beneath the pigment layer of the retina that forms the outer layer of the choroid.

Basal Membrane


in vertebrate animals and man, the boundary film between the epithelium (or endothelium) and underlying loose connective tissue from which it is formed. The basal membrane consists of a diffuse substance and the fibers embedded in it. It serves to strengthen the epithelial layer of cells and prevents its cells from shifting deep into the connective tissue. Impairment of the basal membrane causes the epithelium to grow into the underlying connective tissue (for example, in chronic inflammation and malignant degeneration). The fact that the basal membrane is permeable to some metabolites indicates that it plays a definite part in metabolism.

References in periodicals archive ?
In the kidney, GLUT2 is located in the basolateral membrane where it participates in the release of reabsorbed glucose (Wright et al.
1990), suggest that OAT1 and OAT3 activities localized at the basolateral membrane, which mediate the entries of several endogenous and exogenous substances into the proximal tubule cells, can be influenced earlier by cholesterol accumulation than the effluxing transporters localized apically.
This protein is responsible for iron export from the basolateral membrane of entercytes and release of iron from hepatocytes and macrophages.
In well-differentiated tumors, RAAG12 expression was observed on apical membrane surfaces together with basolateral membrane expression.
Fructose can also cross the basolateral membrane via the activity of GLUT2 (Cheeseman, 1993).
has a similar size and shape to that of iodide, it is able to bind to sodium-iodide symporter (NIS) at the basolateral membrane of the thyroid epithelium, thereby reducing the amount of iodide available for hormone synthesis.
To be released into serum, CD13 should appear on the basolateral membrane (sinusoidal side) before apical transport.
Resorbing osteoclasts are polarized and transport matrix degradation products in transcytotic vesicles from the resorption lacuna to a functional secretory domain in the basolateral membrane (14-16).