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bcl-2
(redirected from Bcl-2 gene)

   Also found in: Wikipedia 0.01 sec.
bcl-2
(biochemistry)
A family of proteins that operate in the effector phase of apoptosis and may either promote or inhibit apoptosis.


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HL-60bcl-2 cells, which are derived from a stable transfectant clone of the human bcl-2 gene into the HL-60 leukemia cell line, show 5-fold greater expression of the Bcl-2 protein compared with HL-60neo cells, a control clone transfected with vector alone.
[FIGURE 3 OMITTED] [FIGURE 4 OMITTED] Effect on p53, c-myc and Bcl-2 gene of SGC-7901 induced by swainsonine: It was clear that the nucleolus or cytoplasm of the positive cell showed yellowish-brown, and the non-staining cells only showed coeruleus nucleolus by microscopic examination.
html ********** The bcl-2 gene was originally identified through studies of the t(14:18) chromosomal translocation associated with human follicular B-cell lymphoma (1-3).
 
 
 
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