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bcl-2
(redirected from Bcl-2 protein)

   Also found in: Wikipedia 0.01 sec.
bcl-2
(biochemistry)
A family of proteins that operate in the effector phase of apoptosis and may either promote or inhibit apoptosis.


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Mcl-1 is part of the Bcl-2 protein family, and is regulated by B-RAF proteins, which are mutated in approximately 60 percent of all human melanomas.
HL-60bcl-2 cells, which are derived from a stable transfectant clone of the human bcl-2 gene into the HL-60 leukemia cell line, show 5-fold greater expression of the Bcl-2 protein compared with HL-60neo cells, a control clone transfected with vector alone.
We performed an immunohistochemical analysis of the expression of proliferating cell nuclear antigen (PCNA) and bcl-2 protein in 15 patients with laryngeal BSCC and 15 stage- and site- matched controls with typical laryngeal SCC.
 
 
 
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