| Dictionary, Encyclopedia and Thesaurus - The Free Dictionary 3,899,167,400 visitors served. |
Dictionary/ thesaurus | Medical dictionary | Legal dictionary | Financial dictionary | Acronyms | Idioms | Encyclopedia | Wikipedia encyclopedia | ? |
Philadelphia chromosome |
Also found in: Medical, Wikipedia | 0.01 sec. |
|
|
Philadelphia chromosome [¦fil·ə¦del·fyə ′krō·mə‚skōp]
(pathology) An abnormally small G-group chromosome found in the hematopoietic cells of most patients with chronic granulocytic leukemia. Want to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit the webmaster's page for free fun content. |
|
| Mentioned in | ? | References in periodicals archive | ? | Encyclopedia browser | ? | Full browser | ? | |||
|---|---|---|---|---|---|---|---|---|---|---|
No references found | Subjects covered include BCR-ABL in hematopoietic stem cell renewal and chronic myeloid leukemia, anti-integrin therapy for hematological malignancies and solid cancers, cell origin of tumors and the persistence of cancer propagating cells in tumor lesions, and ocular limbal stem cell biology and transplantation. Imatinib mesylate, an inhibitor of Bcr-Abl tyrosine kinases, has revolutionized the treatment of chronic myelogenous leukemia (CML), showing marked improvements in survival in all three phases of the disease: chronic, accelerated, and blast crisis (see Figure 1). The resultant fusion protein, BCR-ABL represents an unregulated, permanently switched on tyrosine kinase responsible for phosphorylating tyrosine residues on a number of downstream proteins. |
Bcr-abl |
BCPRU BCPS BCPSA BCPSAG BCPSEA BCPSG BCPSS BCPSSD BCPT BCPTL BCPTP BCPUD BCPV BCPVA BCPVPA BCPWA BCPWHO BCQ BCQC BCQE BCQG BCQHA BCQP BCR BCR Bcr-abl BCRABCRAC BCRAN BCRAO BCRAT BCRB BCRBL BCRBT BCRC BCRCA BCRCB BCRCC BCRCCP BCRCIA BCRCP BCRD BCRDL BCRDS BCREA BCREB BCREC BCREF BCREI BCREQ | |||||||
| Encyclopedia |
| Free Tools: |
For surfers:
Free toolbar & extensions |
Word of the Day |
Help
For webmasters: Free content | Linking | Lookup box | Double-click lookup |
|---|