Bence-Jones protein

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Bence-Jones protein

[¦bens ¦jōnz ¦prō‚tēn]
(pathology)
An abnormal group of globulins appearing in the serum and urine, usually in association with multiple myeloma and characterized by coagulation at 50-60°C.
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Restricted electrophoretic heterogeneity of immunoglobulin light chains in urine: cause for confusion with Bence Jones protein.
The control Bence Jones protein had 2 molecular species that were consistent with monomer and dimer in the presence or absence of physiologic concentrations of salt.
Bence Jones proteins [monoclonal free immunoglobulin light chains (FLCs)] are important tumor markers for identifying and managing patients with monoclonal plasma cell diseases, particularly multiple myeloma.
Also, urine should be sent for protein electrophoresis to look for Bence Jones proteins.
Quantitative assays can have improved sensitivity for immunoglobulins and Bence Jones proteins (4, 5).
A century later, work by Korngold and Lipari (2) characterized Bence Jones proteins and showed that they reacted with those found in myeloma.
Serum free light chains: an alternative to the urine Bence Jones proteins screening test for monoclonal gammopathies.
Serum free light chains: an alternative test to urine Bence Jones proteins when screening for monoclonal gammopathies.