Bence-Jones protein

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Bence-Jones protein

[¦bens ¦jōnz ¦prō‚tēn]
(pathology)
An abnormal group of globulins appearing in the serum and urine, usually in association with multiple myeloma and characterized by coagulation at 50-60°C.
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Pollak, "Renal handling and pathophysiology of Bence Jones proteins," Contributions to Nephrology, vol.
The present case suggests that in patients with [Beta]-migrating Bence Jones proteins and evidence of renal tubular dysfunction, a confirmatory repeat UIFE may be warranted when serial Bence Jones protein levels measured using UPEP with densitometric scanning appear inconsistent with clinical findings (ie, do not decrease with other signs of clinical improvement) or increase unexpectedly.
As a control, we used the urine from a myeloma patient with [kappa] Bence Jones protein without cryo formation.
Bence Jones proteins and light chains of immunoglobulins.
Correlation of serum immunoglobulin free light chain quantitation with urine Bence Jones protein in light chain myeloma [Technical Brief].
Urine Bence Jones proteins was negative and serum electrophoresis pattern was normal in all subjects.
Also, urine should be sent for protein electrophoresis to look for Bence Jones proteins.
In some cases myeloma cells secrete immunoglobulins that contain only the light chains, these are secreted in the urine and are known as Bence Jones proteins (2).