Bence-Jones protein


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Bence-Jones protein

[¦bens ¦jōnz ¦prō‚tēn]
(pathology)
An abnormal group of globulins appearing in the serum and urine, usually in association with multiple myeloma and characterized by coagulation at 50-60°C.
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References in periodicals archive ?
Rectal biopsy, light chains, and Bence-Jones protein were negative.
Tumor markers have been part of the clinical laboratory since the discovery of Bence-Jones protein in 1846.
Multiple myeloma is characterized by excessive numbers of abnormal plasma cells in the bone marrow and overproduction of intact monoclonal immunoglobulin (IgG, IgA, IgD, or IgE) or Bence-Jones protein (free monoclonal light chains).
56 mg/dL, a monoclonal protein identified as IgA-[kappa] with an IgA level of 760 mg/dL, negative Bence-Jones protein in a 24-hour urine sample, and a normal cytogenetic study.