neoplasm (redirected from Benign neoplasm)

neoplasm or tumor, tissue composed of cells that grow in an abnormal way. Normal tissue is growth-limited, i.e., cell reproduction is equal to cell death. Feedback controls limit cell division after a certain number of cells have developed, allowing for tissue repair but not expansion. Tumor cells are less responsive to these restraints and can proliferate to the point where they disrupt tissue architecture, distort the flow of nutrients, and otherwise do damage.

Tumors may be benign or malignant. Benign tumors remain localized as a discrete mass. They may differ appreciably from normal tissue in structure and excessive growth of cells, but are rarely fatal. However, even benign tumors may grow large enough to interfere with normal function. Some benign uterine tumors, which can weigh as much as 50 lb (22.7 kg), displace adjacent organs, causing digestive and reproductive disorders. Benign tumors are usually treated by complete surgical removal. Cells of malignant tumors, i.e., cancers, have characteristics that differ from normal cells in other ways beside cell proliferation. For example, they may be deficient in some specialized functions of the tissues where they originate. Malignant cells are invasive, i.e., they infiltrate surrounding normal tissue; later, malignant cells metastasize, i.e., spread via blood and the lymph system to other sites.

Both benign and malignant tumors are classified according to the type of tissue in which they are found. For example, fibromas are neoplasms of fibrous connective tissue, and melanomas are abnormal growths of pigment (melanin) cells. Malignant tumors originating from epithelial tissue, e.g., in skin, bronchi, and stomach, are termed carcinomas. Malignancies of epithelial glandular tissue such as are found in the breast, prostate, and colon, are known as adenocarcinomas. Malignant growths of connective tissue, e.g., muscle, cartilage, lymph tissue, and bone, are called sarcomas. Lymphomas and leukemias are malignancies arising among the white blood cells. A system has been devised to classify malignant tissue according to the degree of malignancy, from grade 1, barely malignant, to grade 4, highly malignant. In practice it is not always possible to determine the degree of malignancy, and it may be difficult even to determine whether particular tumor tissue is benign or malignant.

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tumour

 or neoplasm

Mass of abnormal tissue that arises from normal cells, has no useful function, and tends to grow. Cell abnormalities may include increased size or number or loss of characteristics that differentiate their tissue of origin. Cells in malignant tumours (see cancer) have a distorted size, shape, and/or structure. Less differentiated cells tend to grow faster. Malignant tumours invade tissues locally and spread (metastasize) in blood or lymph: the stronger the tendency to metastasize, the more malignant the tumour. Tumours may not cause pain until they press on or invade nerves. Both benign and malignant tumours can press on nearby structures, block vessels, or produce excess hormones, all of which can cause death. Benign tumours remain as a solid mass that can be removed by surgery if accessible; they can consist of various tissues and may become malignant; malignant tumours, though they may remain quiescent for a time, never become benign.

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neoplasm [′nē·ə‚plaz·əm]

(medicine)

An aberrant new growth of abnormal cells or tissues; a tumor.