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These tumours need to be distinguished from other benign tumours and aggressive tumours occurring in the same site.
Therefore, while an elevated AFP in a child over 1 year old with a testis tumour almost always reflects the presence of a yolk sac tumour, an elevated level in infants can occur in the setting of a benign tumour.
In benign tumours, there is not enough activity to engage the p53 system, so restoring it has no effect on those tumours.