Benzothiazoles have various known biological properties including antimicrobial and anti-tumorigenic activity (Katnal et al.
Synthesis and biological evaluation of benzothiazole derivatives as potent antitumor agents.
A total of ~640 analogs were synthesized by Epix and/or Amgen chemists to explore the SAR of several chemical series including the two lead series: benzofurans (AMG 277) and benzothiazoles
various alkyl-ammonium compounds, anilides, benzimidazoles, benzothiazoles
, carbamates, guanidine derivatives, imidizoles, isothiazolones, pyrethroides, substituted benzenes and lignins, sulfonamides, thiurams, triazoles, and 2,4-dinitrophenols.
Cure-rite IBT appears to be a reasonable substitute for TMTD, providing improved scorch safety, cure rates and reversion resistance when used with primary accelerators like the benzothiazoles.
type of sulfur crosslinks, characteristics of rubber compounds in which the primary accelerator may be a benzothiazole type like TBBS or CBS.
zClass Speed Amine-aldehyde Slow (condensation products) Guanidines Medium Benzothiazoles
Semi-fast Sulfenamides and sulfenimides Fast, delayed action Dithiophosphates and xanthates Fast Thiurams Very fast Dithiocarbamates Very fast zClass Acronyms Amine-aldehyde (condensation products) Guanidines DPG, DOTG Benzothiazoles
MBT, MBTS Sulfenamides and sulfenimides CBS, TBBS, MBS, DIBS, TBSI Dithiophosphates and xanthates ZBDP Thiurams TMTD, TMTM, TETD Dithiocarbamates ZMDC, ABDC
Sullivan, "Stability of benzothiazole
sulfenamide accelerators," Elastomerics, August, 1981, p.