Thalassemia

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thalassemia

[‚thal·ə′sē·mē·ə]
(medicine)
A hereditary form of hemolytic anemia resulting from a defective synthesis of hemoglobin: thalassemia major is the homozygous state accompanied by clinical illness, and thalassemia minor is the heterozygous state and may not have evident clinical manifestations. Also known as Mediterranean anemia.

Thalassemia

 

(also thalassanemia), a familial hemolytic anemia, first detected in 1925 among inhabitants of the Mediterranean region. Thalassemia is caused by disturbances in hemoglobin synthesis.

References in periodicals archive ?
HE is a rare entity that sometimes present with other haemoglobin disorders like beta thalassaemia, sickle cell anaemia and Hb C.
By calculation there are 25% chances in each pregnancy for this couple to give birth to a beta thalassaemia major child which could have been prevented by avoiding marriage of a thalassaemia minor carrier with thalassaemia minor carrier.
The Department of Haematology at the Inkosi Luthuli Hospital now has between 4 000 and 5 000 gene carriers recorded, the majority of whom have beta thalassaemia.
In these cases investigation of other family members can provide important information regarding the inheritance and segregation of Hb E or beta thalassaemia alleles within the family.
On the first attempt the foetus was found to have beta thalassaemia major and she had an abortion.
The idea was that their IVF baby would be a bone marrow match for their son Zain, who suffers from a potentially fatal blood disorder, beta thalassaemia.
But two attempts to produce a baby to save their four year-old son Zain, who has the rare blood disorder beta thalassaemia, have failed.
17 The current study was planned to examine molecular genetics and prenatal diagnosis of beta thalassaemia to control transfusion-dependent births.
4) The prevalence of beta Thalassaemia trait and sickle cell in India varies between 3-17% and 1-44% respectively.
Seven-year-old Zayed, diagnosed with beta thalassaemia major, received Image Credit: Courtesy: Al Hammadi family Image Credit: Staff Report