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lactam |
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lactam [′lak‚tam] (organic chemistry) An internal (cyclic) amide formed by heating gamma (γ) and delta (δ) amino acids; thus γ-aminobutyric acid readily forms γ-butyrolactam (pyrrolidone); many lactams have physiological activity. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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have a beta-lactam ring that is essential to their activity, the inhibition of bacterial cell wall synthesis. The major metabolite of ertapenem is the inactive ring-opened derivative formed by hydrolysis of the beta-lactam ring. MethylGene has designed, synthesized and developed a family of small molecule inhibitors that do not contain a beta-lactam ring and yet, are able to mimic the inhibitory activity of beta-lactam-based beta-lactamase inhibitors. |
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