lactam

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Related to Beta-lactam Ring: beta-lactamase

lactam

[′lak‚tam]
(organic chemistry)
An internal (cyclic) amide formed by heating gamma (γ) and delta (δ) amino acids; thus γ-aminobutyric acid readily forms γ-butyrolactam (pyrrolidone); many lactams have physiological activity.
References in periodicals archive ?
Carbapenems, including imipenem and meropenem, also contain a bicyclic nucleus with a beta-lactam ring (6).
aeruginosa, become resistant to beta-lactams by either possessing enzymes (beta-lactamases) that hydrolyze the beta-lactam ring or altering the PBPs such that the antimicrobial agent can no longer bind and exert its effect.
Carbapenems are beta-lactam ring structure antibiotics that act similarly to penicillins and cephalosporins by inhibiting synthesis of the bacterial cell wall.

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