lactam

(redirected from Beta-lactam antibiotics)
Also found in: Dictionary, Medical.
Related to Beta-lactam antibiotics: beta-lactamase, Aminoglycosides

lactam

[′lak‚tam]
(organic chemistry)
An internal (cyclic) amide formed by heating gamma (γ) and delta (δ) amino acids; thus γ-aminobutyric acid readily forms γ-butyrolactam (pyrrolidone); many lactams have physiological activity.
References in periodicals archive ?
SYN-004 is intended to block the unintended harmful effects of certain IV beta-lactam antibiotics within the GI tract and maintain the natural balance of the gut microbiome, potentially preventing the 453,000 C.
Synthetic Biologics is developing SYN-004, a novel second generation oral enzyme drug candidate, to be co- administered with commonly used IV beta-lactam antibiotics and is intended to protect the gastrointestinal microflora (microbiome) from the harmful effects of such antibiotics, thus potentially preventing C.
Synthetic Biologics is developing SYN-004, a novel second generation oral enzyme drug candidate, to be co-administered with commonly used IV beta-lactam antibiotics and is intended to protect the gastrointestinal microflora (microbiome) from the harmful effects of such antibiotics, thus potentially preventing C.
A review of cross-reactivity with beta-lactam antibiotics found a high degree of immunologic reactivity between penicillins and imipenem.
This is in contrast to BioTrends and AMR's findings in TreatmentTrends: Gram-Negative Infections (US), where combinations of two beta-lactam antibiotics or a beta-lactam and a fluoroquinolone are the leading therapies prescribed by U.
This analysis also found AVYCAZ was highly active against certain Klebsiella species resistant to other beta-lactam antibiotics, as well as Pseudomonas aeruginosa, including the majority of isolates non-susceptible to meropenem.
The study by researchers at university of Notre Dame and their collaborators in Spain showed how MRSA regulates the critical crosslinking of its cell wall in the face of beta-lactam antibiotics.
aureus, is unnecessary as the methicillin result can be used to predict susceptibility to beta-lactam antibiotics other than penicillin.
Azithromycin is especially useful in patients who have an allergy to beta-lactam antibiotics, and the intravenous formulation is attractive given that oral macrolides, including azithromycin, have low bioavailability, Dr.
Beta-lactam antibiotics represent a class of drugs with a wide spectrum of antibacterial activity, and Orchid is one of the top-five generic beta-lactam antibiotics manufacturers globally.
The use of beta-lactamase inhibitors in combination with beta-lactam antibiotics is currently the most successful strategy to combat a specific resistance mechanism (Lee et al.
1,2,7,8,9) Studies conclude that clinicians should be aware of 1) the possibility of these organisms in their patients (especially if patients have skin/soft-tissue infections), and 2) the fact that these organisms may not be effectively treated with beta-lactam antibiotics.

Full browser ?