AVYCAZ (ceftazidime-avibactam) consists of ceftazidime, a cephalosporin, and avibactam, a non-beta-lactam beta-lactamase
inhibitor, and is approved for the treatment of cIAI (in combination with metronidazole) and cUTI infections including pyelonephritis caused by designated susceptible microorganisms in patients 18 years of age and older.
Emergence and dissemination of Enterobacteriaceae with plasmid-mediated CMY-6 and CTX-M-15 beta-lactamases
in community in North-India.
Evaluation of four commercially available extended-spectrum beta-lactamase
phenotypic confirmatory tests.
These are the injectable beta-lactamase
inhibitor, NXL104, which is being developed in combination with the cephalosporin antibiotic ceftazidime for serious Gram negative infections, and the oral streptogramin antibiotic, NXL103, for the treatment of Gram positive infections, with a focus on treatment in the hospital setting and intravenous (IV) to oral switch.
AmpC disk test for detection of plasmid-mediated AmpC beta-lactamases
in Enterobacteriaceae lacking chromosomal AmpC beta-lactamases
Despite the fact that presence of metallo beta-lactamases
(MBLs) is reported (phenotypically) in various Indian scientific reports, the molecular approach (detection of b/a genes) for their detection is still limited from India.
NXL104 is a novel injectable non beta lactam, beta-lactamase
inhibitor, which is being developed to address the increasing problem of microbial resistance to beta lactam antibiotics (penicillins, cephalosporins, carbopenems) mediated by beta-lactamase
Forest is developing the ceftaroline/NXL 104 combination to treat hospital infections caused by gram-positive pathogens including methicillin-resistant Staphylococcus aureus ("MRSA") and multidrug-resistant Streptococcus pneumoniae ("MDRSP") as well as extended-spectrum beta-lactamase
("ESBL")-producing gram-negative organisms.
It is recognized that the worldwide spread of relatively common hospital pathogens producing multiple beta-lactamases
, including the KPC enzyme, threatens a highly useful class of antimicrobial agents," said Dr.
Nosocomial spread of colistin-only-sensitive sequence type 235 Pseudomonas aeruginosa isolates producing the extended-spectrum beta-lactamases
GES-1 and GES-5 in Spain.
Ceftazidime resistance is used as a marker of ESBL production, as it is hydrolysed by both TEM and SHV type beta-lactamases
Occurrence of TEM and SHV gene in extended spectrum beta-lactamases
(ESBLs) producing Klebsiella sp.