Propiolactone

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Propiolactone

 

(β-propiolactone), an internal cyclic ether of β-hydroxypropionic acid with the structure

Propiolactone is a colorless liquid with a pungent odor, a melting point of –33.4°C, a boiling point of 155°C, and a density of 1.146 g/cm3 (20°C). It is obtained by catalytic interaction of formaldehyde (CH2O) with ketene (CH2=C=O). Solutions and vapors of propiolactone have strong bactericidal effects. Propiolactone is used in medicine for sterilizing blood, vaccines, enzymes, and other biological preparations; it is also used as a fumigant.

References in periodicals archive ?
Each viral strain is harvested via centrifugation and inactivated with beta-propiolactone.
Conventional techniques that are used to inactivate HIV have included formalin treatment, detergent disruption, exposure to psoralen and ultraviolet light, and treatment with beta-propiolactone.
Remune [R] is derived from Zairian HIV-1 strain HZ-321, composed of gp 120-depleted HIV-1 propagated in HUT-78 cells and inactivated in beta-propiolactone and irradiation.