Thalassemia

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Related to Beta-thalassemia: Alpha-thalassemia, Thalassemia minor

thalassemia

[‚thal·ə′sē·mē·ə]
(medicine)
A hereditary form of hemolytic anemia resulting from a defective synthesis of hemoglobin: thalassemia major is the homozygous state accompanied by clinical illness, and thalassemia minor is the heterozygous state and may not have evident clinical manifestations. Also known as Mediterranean anemia.

Thalassemia

 

(also thalassanemia), a familial hemolytic anemia, first detected in 1925 among inhabitants of the Mediterranean region. Thalassemia is caused by disturbances in hemoglobin synthesis.

References in periodicals archive ?
PTG-300 is currently in clinical development for the potential treatment of beta-thalassemia, and may also be potentially beneficial in other diseases such as myelodysplastic syndrome, hereditary hemochromatosis, polycythemia vera, siderophilic infections, and liver fibrosis.
Following the company's upcoming meetings with the US and European regulatory agencies, it intends to initiate a global clinical trial with PTG-300 in patients with beta-thalassemia.
Phenotypic expression of hemoglobin A2 in beta-thalassemia trait with iron deficiency.
Beta-thalassemia disease prevention: genetic medicine applied.
Spectrum of beta-thalassemia mutations in various regions of Punjab and Islamabad, Pakistan: establishment of prenatal diagnosis.
Linear growth in homozygous beta-thalassemia and betathalassemia/hemoglobin E patients under different treatment regimens.
Sickle cell disease and beta-thalassemia are caused by mutations in a gene encoding an adult-expressed subunit termed beta.
Homozygous inheritance of a genetic defect results in the inability of the beta-thalassemia major patients to manufacture beta-globin chains essential for the production of normal adult haemoglobin.
Beta-Thalassemia Minor is Associated with IgA Nephropathy.
from CHOP, along with Rivella and colleagues, investigated in the current study how minihepcidins affected beta-thalassemia and polycythemia vera (PV) in mice separately engineered to model each human disease.