Bio-organic Chemistry

Bio-organic Chemistry


a scientific trend that arose on the boundary between several branches of chemistry and biology in the second half of the 20th century and developed in close association with molecular biology, biochemistry, and other biological disciplines that simultaneously investigate several very important types of substances.

Bio-organic chemistry studies substances that underlie the life processes while striving to understand their biological functions. The main substances studied in bio-organic chemistry are biopolymers (proteins and peptides, nucleic acids and nucleotides, lipids, polysaccharides, and so on), the transformations of which constitute the chemical essence of biological processes; and bioregulators (enzymes, vitamins, and hormones [including plant hormones], as well as synthetic biologically active compounds—for example, drugs, growth substances, insecticides and fungicides, herbicides, and so on), which regulate metabolism chemically. Bio-organic chemistry seeks to obtain these substances in a chemically pure state, determine their structure, synthesize them, discover the relationship between their structure and biological properties, and study the chemical aspects of the mechanism of the biological action of biopolymers and of natural and synthetic bioregulators. Bio-organic chemistry characteristically utilizes the full array of chemical and physical methods of individualizing substances (chromatography, electrophoresis, counterflow distribution, and so on) and ascertains their structure (ultraviolet, infrared, and Raman spectroscopy, magnetic nuclear resonance, electron and proton resonance, chemical mass spectrometry, X-ray diffraction analysis, and so on).

The solution of the main problems of bio-organic chemistry is important for the further progress of biology. Without the elucidation of the structure and properties of the most important biopolymers and bioregulators, it is impossible to gain insight into the nature of the life processes, much less find ways of controlling such complex phenomena as the reproduction and transmission of hereditary signs, normal and malignant cell growth, immunity, memory, and transmission of nerve impulses. Moreover, study of the highly specialized biologically active substances and the processes that take place with their participation may reveal fundamentally new possibilities for the development of chemistry, chemical technology, and engineering. Among the problems whose solution is connected to research in the field of bio-organic chemistry are the creation of strictly specific highly active catalysts (based on a study of the structure and mechanism of action of enzymes), direct conversion of chemical energy into mechanical (based on a study of muscle contraction), the use in engineering of the chemical principles of information storage and transmission found in biological systems, and the principles of self-regulation of multi-component cell systems (chiefly selective permeability of biological membranes). These problems go far beyond bio-organic chemistry proper; however, it creates the preconditions for the elaboration of the problems by maintaining reference points for the development of biochemical research in the field of molecular biology. The range and importance of its problems, the variety of methods, and the close association with other scientific disciplines have enabled bio-organic chemistry to progress rapidly.


Shemiakin, M. M. Sovremennye problemy bioorganicheskoi khimii. Moscow, 1965.
Razvitie organicheskoi khimii ν SSSR. Moscow, 1967. Pages 509–73.
Khokhlov, A. S., and Iu. A. Ovchinnikov. Khimicheskie reguliatory biologicheskikh protsessov. Moscow, 1969.
Bioorganic Chemistry. San Francisco, 1968.


References in periodicals archive ?
He said that hundreds of candidates will be appearing in written and oral examinations in various science disciplines, which includes molecular medicine, organic chemistry, bio-organic chemistry and other branches of chemistry.
Researchers from Brazil's Sao Paulo University and Russia's Institute of Bio-organic Chemistry may now be able to explain why and how certain mushrooms glow in the dark, according to UK newspaper, the Guardian .
A total 90 candidates were selected after written and oral examinations in various disciplines including organic chemistry, analytical/physical/inorganic chemistry, bio-organic chemistry, plant biotechnology, pharmacology, textile chemistry and molecular medicine, Dr.
Important new discoveries were being made in bio-organic chemistry and synthetic organic materials by chemists like Richard Schrock and George Whitesides.
He has an MSc degree in Bio-organic Chemistry from the University of Leiden.
It publishes papers on organic reaction mechanism, theoretical organic chemistry, structure-activity relationships, medicinal chemistry, synthesis of chiral compounds, bio-organic chemistry, enzymes in organic synthesis, reagents in organic synthesis, heterocyclic compounds, phytochemistry (natural products), amino acids, peptides and proteins, spectroscopy in characterization of organic compounds, chemoenzymatic and enantioselective synthesis of organic compounds, synthesis of fullerenes, metalcatalyzed asymmetric reactions, bioactive plant products and combinatorial chemistry.
She was hired as an FQRNT assistant professor of bio-organic chemistry at Universite de Montreal in 1999.
Perhaps new antibiotics are not the only way to combat biofilm infections if we could make ineffective older antibiotics active again," says principal investigator Christian Melander, an associate professor of bio-organic chemistry at North Carolina State University.
Oasmia Pharmaceutical AB is a pharmaceutical company that specialises in the treatment of severe diseases based on the latest concepts in bio-organic chemistry.
Smith III, the Rhodes-Thompson Professor of Chemistry at the University of Pennsylvania and a leading researcher in synthetic organic and bio-organic chemistry.
Lucy, who speaks five languages fluently, has conducted bio-organic chemistry research with a perfect grade-point average of 4.