Biogenic Amines


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Biogenic Amines

 

proteinogenic amines, a group of nitrogen-containing organic compounds that form in human, animal, plant, and bacterial organisms through the decarboxylation (splitting off of the COOH group) of amino acids. Many biogenic amines—histamine, serotonin, noradrenaline, adrenaline, tyramine, and others—are biologically active substances that affect processes of inhibition and excitation in the cerebral cortex and the subcortical centers and evoke changes in blood pressure—by means of vasodilation or vasoconstriction—and other bodily changes. Many biogenic amines that are formed in the large intestine in man and animals by the action of putrefactive bacteria are toxic. Biogenic amines are biologically inactivated primarily by means of oxidative deamination (splitting off of the amino group), which is catalyzed by a group of enzymes—the amine oxidases. Adenosine phosphoric acids, nucleic acids, and high-molecular-weight carbohydrates such as heparin play an important role in the binding of biogenic amines by biochemical cell components. Biogenic amines present in cells in a bound state are inactive and are not affected by amine oxidases.

I. S. SEVERINA

References in periodicals archive ?
Classic" neurotransmitters are called small molecule neurotransmitters or biogenic amines (Eisenhofer 2004).
1995), nitrogen degradability in the rumen of steers, particularly by the biogenic amine (BA) putrescine (Dawson and Mayne, 1997), have negative effects on visceral organs and meat quality (Fusi et al.
Stimulants are contraindicated in persons with hypersensitivity to biogenic amines such as norepinephrine.
Samples were derivatizated and analysed for biogenic amines according to the RP-HPLC procedure proposed by Gomez-Alonso et al.
The important role in organism's adaptation to environmental conditions is due to degree of its maturity and realization of food-seeking and defensive tasks as well as levels of biogenic amines and amino acids in the brain.
Eight biogenic amines were investigated on wines, according to standards of putrescine (PUT) dihydrochloride, spermidine (SPD) trihydrochloride, spermine (SPM) tetrahydrochloride, agmatine (AGM) sulfate, cadaverine (CAD) dihydrochloride, serotonine (SRT) hydrochloride, histamine (HIM) dihydrochloride, tyramine (TYM), tryptamine (TRM) and 2-phenylethylamine (PHM) dihydrochloride purchased from Sigma Chemical Co.
Formation of biogenic amines in raw milk Hispanico cheese manufactured with proteinases and different levels of starter culture.
Histamine is a biogenic amine (sometimes referred to as a vasoactive amine) that, in mammals, is produced primarily by the action of the enzyme histidine decarboxylase on the amino acid histidine.
Similar results were observed using other biogenic amines, such as dopamine and noradrenaline, in the white shrimp L.
Finally, hemolymph levels of biogenic amines (dopamine included) have been shown to increase under unfavourable conditions in several species of insects (Kozanek et al.