bioassay

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Bioassay

A method for the quantitation of the effects on a biological system by its exposure to a substance, as well as the quantitation of the concentration of a substance by some observable effect on a biological system. The biological material in which the effect is measured can range from subcellular components and microorganisms to groups of animals. The substance can be stimulatory, such as an ion increasing taxis behavior in certain protozoans, or inhibitory, such as an antibiotic for bacterial growth. Bioassays are most frequently used when there is a number of steps, usually poorly understood, between the substance and the behavior observed, or when the substance is a complex mixture of materials and it is not clear what the active components are. Bioassays can be replaced, in time, by either a more direct measure of concentration of the active principle, such as an analytical method (for example, mass spectrometry, high-pressure liquid chromatography, radioimmunoassay), or a more direct measurement of the effect, such as binding to a surface receptor in the case of many drugs, as the substance or its mechanism of action is better characterized.

Assays to quantitate the effects of an exposure model the effect of a substance in the real world. Complex biological responses can be estimated by laboratory culture tests, which use, for example, bacteria or cells cultured in a petri dish (usually to model an effect either on the organism of interest, such as bacteria, or on some basic cellular function); by tissue or organ culture, which isolates pieces of tissue or whole organs in a petri dish (usually to model organ function); or in whole animals (usually to model complex organismic relationships).

bioassay

[¦bī·ō′as‚ā]
(analytical chemistry)
A method for quantitatively determining the concentration of a substance by its effect on the growth of a suitable animal, plant, or microorganism under controlled conditions.
References in periodicals archive ?
A general procedure in fluorescence-based assays is to conjugate a fluorophore to some probe and use the fluorescence as an indicator of the presence of the probe molecules in the biological assay [7].
Compared to currently available antibody technology on the market, such as mouse hybridoma, the company's proprietary technology can generate RabMAbs more efficiently and that have superior binding affinity and bioactivity in a wide variety of biological assays.
com) announces updates to their Biological Assay research database.
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The technology is coupled with our Deerac[TM] instruments to make Labcyte a leader in miniaturizing biological assays.
The company will use the funds primarily to create the additional infrastructure needed to meet increased demand for its proprietary biological assays.
This technology enables miniaturization of biological assays.
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The Stratagene Gradient Cycler provides accurate and rapid thermal cycling for PCR amplification and related molecule biological assays.
NASDAQ: QGEN; Frankfurt Prime Standard: QIA) today announced new capabilities for GeneGlobe, the Company's Genes & Pathways web portal providing access to biological assays.
Dotmatics' Vortex is a dynamic analytic and visualization tool designed specifically for the analysis and interrogation of scientific data including chemical structures, biological assays, text, numbers, images and chemical properties.

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