crisis

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Related to Blast crisis: AML

crisis

Pathol a sudden change, for better or worse, in the course of a disease

Crisis

 

a sharp turning point in the course of a disease that is accompanied by a drop in elevated body temperature and improvement in the patient’s condition.

A crisis usually occurs in acute-onset diseases with a rapid rise in temperature (croupous inflammation of the lungs, malaria, relapsing fever, and so forth). A crisis is associated with profuse sweating, marked weakness, and sometimes a temporary slowing of cardiac activity. A crisis is the opposite of a gradual subsidence of a pathological process and lowering in temperature called lysis. A crisis is to be distinguished from a pseudocrisis, in which there is only a temporary lowering of temperature and improvement in the patient’s condition. A critical drop in temperature may also occur as a result of removal of the suppurative focus from the patient’s body or administration of powerful antimicrobial agents.

crisis

[′krī·səs]
(medicine)
The turning point in the course of a disease.
(psychology)
The psychological events associated with a specific stage of life, as an identity crisis or developmental crisis.
References in periodicals archive ?
Furthermore, given the poor median survivals and options for long-term remission or cure in CML blast crisis, prompt and accurate diagnosis of this disease is imperative.
1 CML in blast crisis is usually associated with a history of a chronic phase with basophilia and splenomegaly, as well as the BCR-ABL fusion gene.
Monitoring minimal residual disease and controlling drug resistance in chronic myeloid ABL mutations in late chronic phase chronic myeloid leukemia patients with up-front cytogenetic resistance to imatinib are associated with a greater likelihood of progression to blast crisis and shorter survival: a study by the GIMEMA Working Party on Chronic Myeloid Leukemia.
These findings indicate that the loss of miR-328 is probably essential for progression from the chronic phase of the disease to the blast crisis stage," said principal investigator Danilo Perrotti, associate professor of molecular virology, immunology and medical genetics and a member of the Ohio State University Comprehensive Cancer Center-Arthur G.
CML progresses through three distinct phases: the chronic phase (typically lasting from four to five years), the accelerated phase (typically lasting from six to 18 months) and blast crisis (typically lasting from three to six months).
Researchers also studied the effect of Glivec on patients in blast crisis - 38 had myeloid blast crisis and 20 had acute lymphocytic leukemia or lymphoid blast crisis.
The natural history of CML evolves through a chronic and accelerated phase and terminates in blast crisis.
After a chronic phase of production of too many white blood cells, CML typically evolves to the more aggressive phases referred to as accelerated phase and blast crisis.
Toluidine blue (TB) is a basic dye that helps in identification of myeloid blasts showing differentiation towards basophils, which may be seen in acute basophilic leukemia, basophilic blast crisis of chronic myeloid leukemia (CML) and AML with basophilia.
Emerging evidence from a single European centre study indicates that resistance to imatinib mesylate may occur in approximately 25% of chronic phase CML patients, 41% of accelerated phase patients and 92% of blast crisis patients.
4% of those on imatinib progressed to the accelerated phase or blast crisis of the disease, said lead investigator Dr.