crisis

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Related to Blast crisis: AML

crisis

Pathol a sudden change, for better or worse, in the course of a disease

Crisis

 

a sharp turning point in the course of a disease that is accompanied by a drop in elevated body temperature and improvement in the patient’s condition.

A crisis usually occurs in acute-onset diseases with a rapid rise in temperature (croupous inflammation of the lungs, malaria, relapsing fever, and so forth). A crisis is associated with profuse sweating, marked weakness, and sometimes a temporary slowing of cardiac activity. A crisis is the opposite of a gradual subsidence of a pathological process and lowering in temperature called lysis. A crisis is to be distinguished from a pseudocrisis, in which there is only a temporary lowering of temperature and improvement in the patient’s condition. A critical drop in temperature may also occur as a result of removal of the suppurative focus from the patient’s body or administration of powerful antimicrobial agents.

crisis

[′krī·səs]
(medicine)
The turning point in the course of a disease.
(psychology)
The psychological events associated with a specific stage of life, as an identity crisis or developmental crisis.
References in periodicals archive ?
Fruehauf and colleagues (2007) discussed the combination of mitoxanthrone and etoposide to treat a blast crisis.
Soupir et al3 performed a multi-institutional retrospective analysis of cases of Ph+ AMLs and CML in blast crisis and showed that Ph+ AMLs differed from CML in blast crisis by different clinical pictures (no splenomegaly nor basophilia in Ph+ AML), bone marrow morphology (lower cellularity and myeloid to erythroid ratio in Ph+ AML), cytogenetic findings (characteristic other chromosomal abnormalities usually found in CML were not seen in Ph+ AML), and response to chemotherapy (return to normal karyotype was observed in cases of Ph+ AML, whereas persistence of Ph+ was seen in CML); however, the median survival was similar between the 2 groups.
Our findings also suggest that maintaining the level of this microRNA might represent a new therapeutic strategy for CML blast crisis patients who do not benefit from targeted agents such as imatinib (Gleevec) and dasatinib (Sprycel)," Perrotti added.
CML progresses through three distinct phases: the chronic phase (typically lasting from four to five years), the accelerated phase (typically lasting from six to 18 months) and blast crisis (typically lasting from three to six months).
Researchers also studied the effect of Glivec on patients in blast crisis - 38 had myeloid blast crisis and 20 had acute lymphocytic leukemia or lymphoid blast crisis.
Approximately 3 years after the diagnosis of chronic phase CML, metamorphosis through periods of accelerated growth and blast crisis occur.
Combinations of chemotherapeutic drugs or autologous bone marrow transplantation can also be used for the lymphoid or myeloid blast crisis, but this therapy is more effective if given in the chronic phase of the disease.
It is typically slow-growing and often not diagnosed until its later stages when there can be a sudden, dramatic increase in malignant cells, known as blast crisis.
Tasigna produced deeper levels of molecular response than Glivec in front-line Ph+ CML and significantly reduced progression to accelerated phase and blast crisis, resulting in fewer deaths due to CML.
Toluidine blue (TB) is a basic dye that helps in identification of myeloid blasts showing differentiation towards basophils, which may be seen in acute basophilic leukemia, basophilic blast crisis of chronic myeloid leukemia (CML) and AML with basophilia.
4% of those on imatinib progressed to the accelerated phase or blast crisis of the disease, said lead investigator Dr.
Blood smear revealed increased "vacuolated monocytes," later described as Blast forms indicating possible blast crisis .