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A blood clot occurring on the wall of a blood vessel where the endothelium is damaged.



a clot of blood formed during the lumen of a blood vessel or in the heart. In a broader sense, extravascular clots of blood that form during bleeding, as well as clots of lymph in the lymphatics are also called thrombi.

The formation of a thrombus consists of the following stages: agglutination of platelets, coagulation of fibrinogen, agglutination of red blood cells, and precipitation of plasma proteins. Thrombi may be white, red, laminated, or hyaline. A white thrombus consists of platelets, fibrin, and white blood cells and is formed slowly during rapid blood flow, generally in arteries. A red thrombus, in which red blood cells predominate, forms rapidly during slow blood flow, generally in veins. The most common type of thrombus is the laminated thrombus, which has a layered structure and crimped surface and contains fragments of white and red thrombi. It is attached to the endothelium of a blood vessel, generally that of a vein; this differentiates it from a postmortem thrombus. A hyaline thrombus forms in blood vessels of the capillary bed and consists of a homogenized mass of protein.

A thrombus may be parietal or obstructive. A parietal thrombus forms within the heart in endocarditis and heart disease, in large arteries in atherosclerosis, and in veins in thrombophlebitis. As a parietal thrombus grows, it becomes obstructive, generally in small arteries and veins. A thrombus that grows rapidly into the lumen of a vessel is called progressive, and one that originates in cardiac insufficiency is called congestive. A thrombus that forms in aneurysms is called dilatational; one that is unattached within an atrium is called spherical. A thrombus can dissolve or can grow connective tissue, a process called organization. Thin-walled blood vessels may appear in this tissue (canalization), or calcium salts may be deposited (calcification). A thrombus may cause an embolism or may become purulent, a condition accompanied by a thrombobacterial embolism and leading to sepsis.


References in periodicals archive ?
It is estimated up to 10,000 people die of undetected blood clots each year in Australia.
Known as CALLISTO, the new oncology research program is part of Janssen and Bayer HealthCare's broader EXPLORER clinical development program, evaluating patient populations being treated for blood clots or at high risk for developing them.
The results showed people who had taken anti-psychotic drugs in the previous two years had a 32% greater risk of any type of blood clot.
They also told her that running played a significant role in her survival, because the cardiovascular strength or stamina she previously achieved through running helped her heart react more strongly and successfully to the challenge the blood clots posed, and also helped her recover more swiftly.
There is a huge education gap concerning hospital acquired blood clots.
David Curb, a geriatrician at the University of Hawaii in Honolulu, who coauthored the blood clot study.
BB-10153's extended half-life (three to four hours) enables it to persist in the blood as an inactive pro-drug, activated only at fresh or forming blood clots by the thrombin that is localized there.
All patients with such blood clots suffer some damage, he added, noting: ``The hemorrhage itself causes some degree of brain damage.
The new AngioJet Ultra System includes an advanced microprocessor-based console and family of disposable thrombectomy sets designed to quickly and safely remove blood clots from arteries and veins.
NEW YORK, March 5, 2015 /PRNewswire-USNewswire/ -- NYU Langone Medical Center has announced the creation of a new multidisciplinary Venous Thromboembolic Disease Center (VTEC) to treat those with life-threatening blood clots.
Two experimental pills could become alternatives to a class of drugs that's used widely to protect surgical patients against potentially fatal blood clots.
Onions contain substances that help prevent blood clots from forming inside the walls of plaque-filled heart arteries.