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blood groups |
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blood groups, differentiation of blood by type, classified according to immunological (antigenic) properties, which are determined by specific substances on the surface of red blood cells. Blood groups are genetically determined and each is characterized by the presence of a specific complex carbohydrate carbohydrate, any member of a large class of chemical compounds that includes sugars, starches, cellulose, and related compounds. These compounds are produced naturally by green plants from carbon dioxide and water (see photosynthesis ). ..... Click the link for more information. . About 200 different blood group substances have been identified and placed within 19 known blood group systems. The most commonly encountered blood group system is the ABO, or Landsteiner Landsteiner, Karl (kärl länt`shtīnər), 1868–1943, American medical research worker, b. Vienna, M.D. Univ. ..... Click the link for more information. , system. Individuals may contain the A, B, or both A and B antigenic substances, or else lack these substances (type O). In the ABO system an individual who lacks one or more of these antigens will spontaneously develop the corresponding antibodies antibody, protein produced by the immune system (see immunity ) in response to the presence in the body of antigens: foreign proteins or polysaccharides such as bacteria, bacterial toxins , viruses, or other cells or proteins. ..... Click the link for more information. (agglutinins) shortly after birth. Thus a person with A type blood will naturally produce anti-B agglutinins, a person with B blood will produce anti-A agglutinins, and a person with O blood will produce anti-A and anti-B agglutinins; but a person with AB blood will not produce any agglutinins in this blood group system. Since these agglutinins are always present in the blood, in blood transfusion blood transfusion, transfer of blood from one person to another, or from one animal to another of the same species. Transfusions are performed to replace a substantial loss of blood and as supportive treatment in certain diseases and blood disorders. ..... Click the link for more information. the donor blood must be compatible with the recipient's blood, i.e., the donor's blood must not contain antigen corresponding to the recipient's antibody. Other blood group systems, such as the MNSs, Lewis, Lutheran, and P systems, are not as important in transfusion because they act like true antigen-antibody systems, i.e., antibodies do not appear in blood plasma until the individual has been immunized by exposure to the other blood group antigens as in previous transfusions. In general, blood group substances are weak antigens, and antibody formation after transfusion occurs less than 3% of the time. Immunization can occur by pregnancy as well as by transfusion. Thus, in the Rh factor Rh factor, protein substance present in the red blood cells of most people, capable of inducing intense antigenic reactions. The Rh, or rhesus, factor was discovered in 1940 by K. Landsteiner and A. S. ..... Click the link for more information. blood group system, an Rh-negative mother carrying an Rh-positive fetus produces anti-Rh antibodies against fetal red blood cells that cross the placenta. Since blood type is a genetic trait that is easy to test and the blood type of an individual is related to his or her parent's blood types by the laws of Mendelism (see under Mendel, Gregor Mendel, Gregor Johann (grā`gôr yō`hän mĕn`dəl) ..... Click the link for more information. ), blood group typing is used legally to establish paternity. Anthropologists use the frequency of occurrence of various blood groups as tools to study racial or tribal origins. |
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| There are four ABO blood groups based on the presence or absence of two specific antigens--A and B--and two Rh blood groups. It is important that Tisseel's effects be studied in nonhuman primates because their blood groups (23,24) and coagulation cascade (25,26) are similar to those of man. Everyone belongs to one of four blood groups (A, B, O, or AB), determined by genes, or hereditary material passed from parents to children. |
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