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coagulation |
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coagulation (kōăg'y lā`shən), the collecting into a mass of minute particles of a solid dispersed throughout a liquid (a sol), usually followed by the precipitation or separation of the solid mass from the liquid. The casein in milk is coagulated (curdled) by the addition of acetic acid or citric acid. The albumin in egg white is coagulated by heating. The clotting of blood is another example of coagulation. Coagulation usually involves a chemical reaction. Lyophobic particles (see colloid colloid (kŏl`oid) [Gr.,=gluelike], a mixture in which one substance is divided into minute particles (called colloidal particles) and..... Click the link for more information. ) lose their electric charge by reacting with oppositely charged particles. Lyophilic particles undergo a reaction that causes them to lose their solubility. In either case coagulation occurs. The formation of a gel by evaporation or cooling of a sol is usually called gelation rather than coagulation. coagulationProcess of forming a blood clot to prevent blood loss from a ruptured vessel. A damaged blood vessel stimulates activation of clotting factors, eventually leading to the formation of long, sticky threads of fibrin. These make a mesh that traps platelets, blood cells, and plasma. This meshwork soon contracts into a resilient clot that can withstand the friction of blood flow. Under abnormal circumstances, clots can form in an intact vessel and may block it. See also anticoagulant. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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Conjugating PolyXen(r) to therapeutic blood-clotting factors aims to improve pharmacokinetic profile and extend active life in order to reduce the frequency of injections required to treat blood-clotting disorders such as haemophilia A. Any of the various dissolved proteins of blood plasma, including antibodies and blood-clotting proteins, that act by holding fluid in blood vessels by osmosis. The suit, filed in federal court in San Francisco on behalf of class members in Asia, Latin America, and Europe, claims that the companies continued to sell blood-clotting agents to foreign countries even after they knew that the products could be tainted with HIV or hepatitis C. |
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