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osteogenesis imperfecta
(redirected from Brittle bone disease)

   Also found in: Dictionary/thesaurus, Medical, Legal, Wikipedia 0.02 sec.

osteogenesis imperfecta

Group of connective-tissue diseases in which the bones are very fragile. Several forms probably reflect different degrees of expression of the same disorder. Persons with osteogenesis imperfecta type I are normal at birth, but fractures occur easily; in van der Hoeve syndrome the sclerae are bluish, bone deformities in the skull cause deafness, double-jointedness occurs, and skin is abnormally thin. Babies with osteogenesis imperfecta type II, if not stillborn, are born with fractures, and fractures continue to occur, causing severe crippling; survival to adulthood is rare.


osteogenesis imperfecta [¦äs·tē·ō′jen·ə·səs ‚im·pər′fek·tə]
(medicine)
A disease inherited as an autosomal dominant and characterized by hypoplasia of osteoid tissue and collagen, resulting in bone fractures.


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THOUSANDS of patients with crippling brittle bone disease are being denied the treatment they need because of a drug approval system that "defies logic", it was claimed last nigtht Up to 5% of osteoporosis sufferers under the care of doctors in England and Wales could be affected, according to a leading expert.
Among the cells they produced were osteoclasts, large white cells involved in the brittle bone disease osteoporosis, and eosinophils, which play a role in allergy and asthma.
Byline: ANI Washington, August 5 (ANI): Researchers at the Massachusetts Institute of Technology (MIT) have for the first time carried out a multi-scale analysis to shed light on how bone's material flaws lead to brittle bone disease.
 
 
 
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