Summary of specimens and testing for agents of bioterrorism ORGANISM SPECIMENS (VARIES WITH SYMPTOMS) Bacillus anthracis Blood, vesicular fluid, skin scrapings, sputum, rectal swab or feces Clostridium botulinum Feces, enema, gastric aspirate, (toxin) serum (3 ml minimum), tissue Brucella species Blood, bone marrow, liver, spleen, joint fluid, serum Francisella tularensis Blood, respiratory, tissues, serology Yersinia pestis Blood, lower respiratory, tissue; liver, spleen bone marrow, serum Burkholderia mallei
Blood, respiratory, tissues, serum Burkholderia pseudomallei Blood, respiratory, tissues, serum, urine Staphylococcus aureus Nasal wash, induced sputum, urine, (enterotoxin B producer) feces, gastric aspirate, post-mortem tissue, serum, S.
Glanders is an infectious disease - caused by infection with the bacterium Burkholderia mallei
- usually by ingestion of contaminated food or water that occurs primarily in horses and can be easily spread.
Solithromycin is a clinical-stage fluoroketolide antibiotic with potent and broad-spectrum activity against gram-positive and gram-negative pathogens, including multidrug-resistant strains, non-bacterial pathogens such as Plasmodium falciparum and a variety of bio-defense pathogens including Bacillus anthracis, Yersinia pestis, Burkholderia mallei
and Francisella tularensis.