cyclic AMP-dependent protein kinase

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cyclic AMP-dependent protein kinase

[¦sī·klik ¦ā¦em¦pē di¦pen·dənt ‚pro‚tēn ′kī‚nās]
(biochemistry)
A serine/threonine protein kinase that phosphorylates a variety of substrates and regulates many important processes such as cell growth and differentiation and the flow of ions across the cell membrane. Also known as protein kinase A; PKA.
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Characterization of agonist stimulation of cAMP-dependent protein kinase and G protein-coupled receptor kinase phosphorylation of the beta2-adrenergic receptor using phosphoserine-specific antibodies.
PKA, also called cAMP-dependent protein kinase A, is organized as tetramers comprising two catalytic and two regulatory subunits.
For positive control along with reaction mixture dilutions (using PKA dilution buffer- 380 mM K3PO4 andmM DTT) of cAMP-dependent protein kinase in variable concentrations (0.
1992) Catalytic subunits of Aplysia neuronal cAMP-dependent protein kinase with two different N termini.
We examined Boa's ability to activate different downstream signaling transduction pathways (kinases) by retreating GC-1 cells with the PKG inhibitor KT5823, the ERK inhibitor PD98059, the G[alpha]i/G[alpha]q inhibitor peruses toxin (PTX), the Src inhibitor PP2, the EGFR inhibitor AG-1478, the cAMP-dependent protein kinase (PKA) inhibitor H89, and the G[alpha]s inhibitor NF449 before 12-hr exposure to 10(-9) M BPA, a concentration that provided maximum cell proliferation and then evaluated cell viability using the MTT assay.
In this study we established cooperative interaction between substrate binding sites of the cAMP-dependent protein kinase catalytic subunit (protein kinase A, EC 2.
The CAMP-dependent protein kinase substrate Rapt in platelets from patients with obsessive compulsive disorder or schizophrenia.
The enzyme was expressed in Escherichia coli [9] and thereafter stoichiometrically phosphorylated by the catalytic subunit of cAMP-dependent protein kinase [10].
Initially we studied the participation of the cAMP-dependent protein kinase (PKA).
9:50 BREAK 10:10 "Phosphorylation of the type I regulatory subunit of cAMP-dependent protein kinase in rat tissues.
For example, catecholamine rapidly activates the [beta]-adrenergic receptor and the cAMP-dependent protein kinase A (PKA) axis (McKnight et al.
But the trio acted synergistically to upregulate a regulatory subunit of cAMP-dependent protein kinase, a ubiquitous protein involved in neurologic pathways and a key regulator of neuronal growth in the clam embryo model.

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