The two people have a mutation in each of their two copies of the CC-CKR-5 gene, the researchers report in the Aug.
A research group headed by Marc Parmentier of the Free University of Brussels found the same CC-CKR-5 gene mutation when they screened 704 white people from France and Belgium.
Researchers are increasingly excited about preventing or treating many HIV infections with compounds that bind to CC-CKR-5 and thus stop the virus from using the protein to infect cells.
Like fusin, CC-CKR-5 is a receptor, a protein that normally binds to extracellular molecules and transmits signals into the cell.
As it turns out, CC-CKR-5 is the receptor for RANTES, MIP1-alpha, and MIP1-beta, chemokines already attracting the attention of AIDS investigators.
Taken together, these results suggest that the binding of chemokines to CC-CKR-5 can sometimes prevent HIV from infecting a person, investigators contend.
At least three different research groups have recently linked HIV's ability to infect immune cells to CC-CKR-5.
The third report on CC-CKR-5, scheduled to appear in the June 28 Science, results from a collaboration headed by Philip M.
Doms' group has found at least one HIV strain that can infect cells using either fusin or CC-CKR-5.