CCR5

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CCR5

(medicine)
Belonging to the seven-transmembrane chemokine receptor family, the major cofactor for primary macrophage-tropic human immunodeficiency virus-1 strains.
References in periodicals archive ?
One of the chemokine receptors, CCR-5, which along with CD4 acts as co-receptor for HIV entry into macrophages, provides upon mutation a genetic restriction to HIV infection in homozygous persons and control of disease progression in heterozygous persons (5.
However, no such mutation is seen in Japanese, Native Americans, Chinese, Africans, and Tamil Indians, which suggests that in these groups either resistance to HIV infection is not present or factors other than mutated CCR-5 are in operation.
We, therefore, studied for the first time the mutation of CCR-5 in Arabs residing in Saudi Arabia.