CCR5


Also found in: Medical, Acronyms, Wikipedia.

CCR5

(medicine)
Belonging to the seven-transmembrane chemokine receptor family, the major cofactor for primary macrophage-tropic human immunodeficiency virus-1 strains.
References in periodicals archive ?
To determine the prevalence of Rs333 polymorphism located in the CCR5 gene, we designed a cross-sectional study with HIV-infected patients living in Roraima, who had blood sent for analyses at the Central Laboratory of Roraima State (LACEN/RR).
Cell lysis, protein quantification and immunoblot experiments were conducted as described previously, [11] using a specific CCR5 antibody.
The study showed that the prevalence of CCR5 positivity was 88.
To the best of our knowledge there are no data of this variant in the Bosniak population, which would complement the gaps in epidemiology European frequency of [DELTA]32 allele CCR5.
Since one of the effects of the research is to replicate CCR5 delta 32 mutation found in a limited number of people Europe, certain risks must be considered.
Each patient received one dose of the autologous CD4+ T-cell product in which the gene for CCR5, a coreceptor for HIV entry, is modified via zinc-finger nuclease (ZFN)-mediated genome editing.
A minority of HIV strains also use the alternate co-receptor CXCR4 instead of CCR5.
They used the same nuclease to zero in on an undamaged section of the CCR5 receptor's DNA.
That same receptor has now been found to be critical to the ability of certain strains of Staph to specifically target and kill cells with CCR5, which orchestrate an immune response against the bacteria.
For HIV, we have used a small interfering ribonucleic acid (siRNA) targeted to CCR5.
According to Cannon, T cells' weak link is a gene called the CCR5.