cytotoxic T cell

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Related to CD8+ T cells: lymphocyte activation

cytotoxic T cell

[¦sīd·ə‚täk·sik ′tē ‚sel]
(immunology)
A type of T cell which protects against pathogens that invade host cell cytoplasm, where they cannot be bound by antibodies, by recognizing and killing the host cell before the pathogens can proliferate and escape.
References in periodicals archive ?
CD38 expression on cryopreserved CD8+ T cells predicts HIV disease progression.
Depletion of CD8+ T cells reduces the capacity of primed mice to respond to influenza infection, which indicates a role for CD8+ T cells in the protective secondary response.
New knowledge about the way the cells function might lead to vaccines which avoid the development of poorly functioning CD8+ T cells.
These lower limits of detection corresponded to as few as of 230 CD4+ or 125 CD8+ T cells in the assay wells.
One reason this may occur is due to the presence of CD8+ T cells with particular functional characteristics.
Using the markers CD38 and HLA-DR on CD8+ T cells they showed that, in patients with a good response to ART (undetectable viral load at 6 and 12 months), there was a rapid fall in activation during the first 6 months of treatment.
Absolute CD4+ and CD8+ T cell counts are measurements used to monitor disease progression in HIV/AIDS patients, to determine when to begin treatment with antiretroviral drugs and to monitor a patient's response to treatment.
The published paper notes the findings of other research that, to be effective, a cancer vaccine should produce both CD8+ T cells (such as CTLs) that bind to antigenic peptides in association with MHC Class I molecules, and CD4+ "helper" T cells that bind to antigens in the context of MHC Class II molecules.
Washington, May 18 (ANI): Researchers at Duke University Medical School and Mount Sinai School of Medicine have discovered a new role for a host protein that provides further insight into how CD8+ T cells work to control HIV and other infections.
In preclinical studies using the Eligix Separation System, high levels of CD8+ T cells were selectively depleted, while the immune cells and stem cells that are necessary to repopulate into the different blood cells, which the body needs, were preserved.