cytotoxic T cell

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Related to CD8 T cell: CD4 T cells, Memory T cells

cytotoxic T cell

[¦sīd·ə‚täk·sik ′tē ‚sel]
(immunology)
A type of T cell which protects against pathogens that invade host cell cytoplasm, where they cannot be bound by antibodies, by recognizing and killing the host cell before the pathogens can proliferate and escape.
References in periodicals archive ?
Professor Lalvani said that the immune system produces these CD8 T cells in response to usual seasonal flu.
Antigen-independent memory CD8 T cells do not develop during chronic viral infection.
This study reports T cell activation defined by CD38 and HLA-DR with quantitative assessment of CD38 and compares these measures of immune activation with serological markers, and uses proportional hazards modelling to demonstrate that CD8 T cell activation defined by CD38 expression was the strongest predictor of clinical progression [4].
These new assays were based on measuring antigen-specific cytokine production in both CD4 and CD8 T cells from HIV-infected people.
As in the study reviewed here, this development and expansion of CD4 and CD8 T cells appears to result in an immune system recovery which may be associated with a lower incidence of opportunistic infections and a longer life expectancy, a clinical benefit that we hope to demonstrate in future large-scale randomized clinical studies.
In this study, the level of CD38 expression, above which CD8 T cells were defined as activated, was not clearly stated.
Studies in rhesus monkeys have shown that significant and persistent virus-specific T cell responses can be elicited with vaccines incorporating viral genetic sequences and that these responses are primarily mediated by CD8 T cells.
Generation of genome-wide CD8 T cell responses in HLA-A*0201 transgenic mice by an HIV-1 ubiquitin expression library immunization vaccine.
In every participant, the vaccine engendered antibodies against circumsporozoite and whipped up an army of immune system warriors called CD4 and CD8 T cells, says study coauthor Giampietro Corradin, a biochemist at the University of Lausanne in Epalinges, Switzerland.
Evaluate whether any observed changes in CD4 and CD8 T cell counts are due to increasing thymic output and/or peripheral T cell expansion
After 48 weeks, patients treated at the higher dose level showed a median increase in CD4 and CD8 T cell counts (cells/microliters) of 75% and 58%, respectively, from baseline levels.
The study data also showed enhanced HIV-specific CD4 and CD8 T cell activity in these patients.