Professor Lalvani said that the immune system produces these CD8 T cells
in response to usual seasonal flu.
Antigen-independent memory CD8 T cells
do not develop during chronic viral infection.
This study reports T cell activation defined by CD38 and HLA-DR with quantitative assessment of CD38 and compares these measures of immune activation with serological markers, and uses proportional hazards modelling to demonstrate that CD8 T cell
activation defined by CD38 expression was the strongest predictor of clinical progression .
These new assays were based on measuring antigen-specific cytokine production in both CD4 and CD8 T cells
from HIV-infected people.
As in the study reviewed here, this development and expansion of CD4 and CD8 T cells
appears to result in an immune system recovery which may be associated with a lower incidence of opportunistic infections and a longer life expectancy, a clinical benefit that we hope to demonstrate in future large-scale randomized clinical studies.
In this study, the level of CD38 expression, above which CD8 T cells
were defined as activated, was not clearly stated.
Studies in rhesus monkeys have shown that significant and persistent virus-specific T cell responses can be elicited with vaccines incorporating viral genetic sequences and that these responses are primarily mediated by CD8 T cells
Generation of genome-wide CD8 T cell
responses in HLA-A*0201 transgenic mice by an HIV-1 ubiquitin expression library immunization vaccine.
In every participant, the vaccine engendered antibodies against circumsporozoite and whipped up an army of immune system warriors called CD4 and CD8 T cells
, says study coauthor Giampietro Corradin, a biochemist at the University of Lausanne in Epalinges, Switzerland.
Evaluate whether any observed changes in CD4 and CD8 T cell
counts are due to increasing thymic output and/or peripheral T cell expansion
After 48 weeks, patients treated at the higher dose level showed a median increase in CD4 and CD8 T cell
counts (cells/microliters) of 75% and 58%, respectively, from baseline levels.
The study data also showed enhanced HIV-specific CD4 and CD8 T cell
activity in these patients.