cytotoxic T cell

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Related to CD8 T cells: CD4 T cells, Cytotoxic T lymphocytes

cytotoxic T cell

[¦sīd·ə‚täk·sik ′tē ‚sel]
(immunology)
A type of T cell which protects against pathogens that invade host cell cytoplasm, where they cannot be bound by antibodies, by recognizing and killing the host cell before the pathogens can proliferate and escape.
References in periodicals archive ?
To quantify the number of CD38 molecules by flow cytometry, the methods used are based upon the mean or median fluorescence value for CD8 T cells gated onto a CD38 histogram.
The authors concluded that this study indicated that each of the three herbs activated CD4 T cells and CD8 T cells, and that this immune activation appeared greater when all three herbs were taken together.
However, the reality is that most infected people make sufficient and even robust antibody and CD8 T cell responses to HIV.
CD8 T cell CD38 expression is hugely increased in HIV infection [34] and has been shown to be an important prognostic marker in patients before they start ART, independent of CD4 count and viral load [36].
High frequencies of the cells were found in both groups, but only those in nonprogressors were found to maintain high proliferative capacity, which was directly coupled with increases in expression of perforin--a molecule that helps CD8 T cells eliminate cells infected with HIV (Nat.
Studies at two independent laboratories showed that rhIL-7 markedly improved host survival, blocked apoptosis of CD4 and CD8 T cells, restored IFN- production, and improved immune effector cell recruitment to the infected site.
In addition to getting instructions from the antigen-presenting cells, CD8 T cells need assistance from helper T cells to become effective killers.
In every participant, the vaccine engendered antibodies against circumsporozoite and whipped up an army of immune system warriors called CD4 and CD8 T cells, says study coauthor Giampietro Corradin, a biochemist at the University of Lausanne in Epalinges, Switzerland.
However, prior studies have shown that chronic activation of CD8 T cells is associated with CD4 T cell loss.
IL-7 represents a promising investigative therapy which has shown in pre-clinical and Phase I studies in oncology and in HIV-infected patients to be well tolerated in repeated dose trials, with long-lasting increases in both CD4 and CD8 T cells.
The study showed that rapamycin, given to transplant patients to suppress their immune system, can trigger the formation of memory CD8 T cells, enabling the immune system to respond faster upon secondary encounter.
high levels of CD8 T cells (cytotoxic T lymphocytes) specific for proteins produced from the key viral genes gag, pol and env (J Virol, 69:9, p.