IAB22M2C shows potential for whole-body imaging of CD8 T-cells in patients treated with immunotherapies
Immuno-imaging of tumor-infiltrating CD8 T-cells with radiolabeled antibody fragments could provide a specific and sensitive modality to achieve this goal.
In addition to providing further evidence of the ability of IL-7 to stimulate the expansion of CD4 and CD8 T-cells
in peripheral blood, the results demonstrate the importance of IL-7 in stimulating T-cell repopulation of the lymphoid tissue layer in the mucous membrane of the GI tract.
Of 24 positive CD4 or CD8 T-cell
responders following the third and last vaccination in month 3, 79% (19/24) showed persistent CD4 or CD8 T-cell
responses at month 9.
Delivery of the fourth vaccination increased the frequency and magnitude of the CD8 T-cell
and Antibody responses
On September 26 scientists at the Aaron Diamond AIDS Research Center (ADARC) announced that they had identified a significant contributor to a long-sought antiviral factor, secreted by certain CD8 T-cells
, that inhibits HIV replication.
As part of the 1101 study, we are evaluating whether an improvement in HIV control can be obtained by including CD8 T-cells
in our SB-728-T product, mimicking a phenotype observed in 'elite controllers.
Prior research has demonstrated that CD4 and CD8 T cells are both important in cellular immune responses; however, CD8 T-cells
, or killer T cells, are considered especially integral to fighting cancers and chronic infectious diseases.
TAT0002 was previously shown to stimulate the production of IFN-gamma -- a molecule involved in the anti-viral response of cytotoxic CD8 T-cells
specific for the HIV-1 AIDS virus -- and to enhance the ability of the CD8 cells to proliferate and kill HIV-1-infected CD4 cells.
Many studies indicate that CD8 T-cells
are a critical component of the immune response which can control HIV.
a joint venture between Geron Corporation and the Biotechnology Research Corporation of Hong Kong (BRC), announced today the presentation of studies demonstrating that their small molecule telomerase activator, TAT0002, enhances the anti-viral activity of CD8 T-cells
from HIV/AIDS donors against infected CD4 cells from the same donors.
Recent clinical data from other WT1 peptide immunotherapeutics stimulating CD8 T-cells
has been very positive.