CYT107 also decreased PD-1 frequency, a marker of T cell exhaustion, in both CD4 and CD8 T-cells
at W12 (p=0.
The minibodies are linked to Zirconium-89, illuminating CD8 T-cells
to provide a whole-body picture of immune response.
Data generated using Poly-ICR, in combination with a tumor-associated antigen, have demonstrated that the addition of the adjuvant potently increases the antigen-specific CD8 T-cell
levels, which correlated with regression of tumors and prevention of tumor growth in mouse models.
CD4 and CD8 T-cells
are both important in cellular immunity, however, CD8 T-cells
are considered especially integral to fighting cancers and chronic infectious diseases.
This new mixed CD4/CD8 SB-728-T cell product not only has the potential to improve the antiviral effect of the treatment, but significantly simplifies the manufacturing process as we have eliminated the step of removing CD8 T-cells
from the modified product.
Effros' team also showed that Geron's small molecule telomerase activators had similar activity enhancing the ability of certain HIV-specific CD8 T-cells
to inhibit virus production when co-cultured with an HLA-matched HIV-infected CD4 T-cell line.
In this study, ZFNs were used to disrupt the native TCR genes in these tumor-directed CD8 T-cells
resulting in an enhanced immunotherapeutic product with potent cancer cell-killing activity and the elimination of GvHD in a mouse model.
Recent clinical data from other WT1 peptide immunotherapeutics stimulating CD8 T-cells
has been very positive.
A booster shot of this vaccine stimulated the immune system in a manner thought to be important for protection against TB, which included activation of CD4 and CD8 T-cells
This exciting study follows favorable observations from the administration of TGF alpha to a sick, but non-SIV-infected rhesus monkey which showed an 88% increase in CD4 T-cell counts and increases in CD8 T-cells
as well as CD4/CD8 T-cell
precursor cells in response to the treatment," commented Dr.
The other half of the patients will receive the DC vaccinations plus ZADAXIN, which has been shown to significantly increase the levels of CD4 and CD8 T-cells
Statistically significant increases were noted in activated CD8 T-cells
(37 of 37 patients), dendritic cells (34/35) and natural killer and lymphokine-activated killer cells (33/36).