CCR5

(redirected from CKR-5)
Also found in: Medical.

CCR5

(medicine)
Belonging to the seven-transmembrane chemokine receptor family, the major cofactor for primary macrophage-tropic human immunodeficiency virus-1 strains.
References in periodicals archive ?
Global Markets Direct's, 'C-C Chemokine Receptor Type 5 (C-C CKR-5 or CHEMR13 or HIV-1 Fusion Coreceptor or CD195 or CCR5) - Pipeline Review, H1 2016', provides in depth analysis on C-C Chemokine Receptor Type 5 (C-C CKR-5 or CHEMR13 or HIV-1 Fusion Coreceptor or CD195 or CCR5) targeted pipeline therapeutics.
The report provides comprehensive information on the C-C Chemokine Receptor Type 5 (C-C CKR-5 or CHEMR13 or HIV-1 Fusion Coreceptor or CD195 or CCR5), targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type.
AIDS cofactor identified: Five teams of researchers identify, virtually simultaneously, a single protein called CKR-5 that allows the AIDS virus to establish a foothold in the body.
Most people have two normal copies of a gene that directs production of a protein called CKR-5 on the surface of white blood cells.
While it seems reasonable that having mutations in both copies of the CC- CKR-5 gene offers considerable protection from infection with HIV, scientists caution that several HIV strains use molecules other than CC- CKR-5 to infect cells.
The gene is called CKR-5 and the protein it makes is located on the surface of certain immune cells.