We have recently reported that dexamethasone represses both hypoxia-induced COX-2 and induction of GILZ is a key event in hypoxia-induced COX-2 inhibition
by glucocorticoids (Lim et al.
Importantly, selective COX-2 inhibition
may represent a potential therapeutic method for impaired urinary concentration capacity in children with congenital pelvic-ureteral junction obstruction.
Studies are a dime a dozen as to "how" COX-2 inhibition
reduces arthritic inflammation and menstrual pain and, in so doing, "prevents" certain cancers--most notably of the colon.
It was therefore not surprising to observe in our pharmacogenomic studies that COX-2 inhibition
, by altering the profile of eicosanoids spontaneously generated by diseased OA cartilage, resulted in profound effects on the transcription of multiple genes that could alter cartilage homeostasis.
A Merck-sponsored study involving a genetically altered mouse model came to this conclusion: "Lesion analysis showed that selective Cox-2 inhibition
11) also reported that selective COX-2 inhibition
can improve endothelial function and decrease inflammation in severe coronary artery disease.
Although experiments indicate that Cox-2 inhibition
suppresses the development of benign growths, such as polyps, solid data showing that these drugs prevent cancer in people are still lacking, Ristimiiki says.
The inhibition of COX-1 activity has been associated with the gastrointestinal toxicity of the traditional nonsteroidal anti-inflammatory drugs (NSAIDs), while COX-2 inhibition
is responsible for the anti-inflammatory effects of the NSAIDs.
Still, he believes there is room for a drug with less specific COX-2 inhibition
, since not everybody responds to or tolerates Celebrex and Vioxx, added Dr.
Shixin Deng (China) - DAA effect on sodium channel inhibition and COX-2 inhibition
Three recent clinical trials also showed pain relief and a reduced need for pain medication in arthritis patients after taking Pycnogenol , results that are linked to COX-2 inhibition
Utilizing PhytoLogix, researchers screened over 1230 organic plant extracts for potential COX-2 inhibition