cox-2 inhibitor

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Related to COX-2 inhibition: Coxibs

cox-2 inhibitor:

see nonsteroidal anti-inflammatory drugnonsteroidal anti-inflammatory drug,
a drug that suppresses inflammation in a manner similar to steroids, but without the side effects of steroids; commonly referred to by the acronym NSAID .
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References in periodicals archive ?
To examine whether TRPA1 activation is involved in COX-2 inhibition by methyl syringate, we examined whether the selective TRPA1 antagonist F1C-030031 blocked the effects of methyl syringate on COX-2 protein expression.
Grosser, "The cardiovascular pharmacology of COX-2 inhibition," Hematology/The Education Program of the American Society of Hematology, vol.
Studies are a dime a dozen as to "how" COX-2 inhibition reduces arthritic inflammation and menstrual pain and, in so doing, "prevents" certain cancers--most notably of the colon.
The scientists are pursuing other potential applications of activating endocannabinoids by substrate-selective COX-2 inhibition, including relieving pain, treating movement disorders, and possibly preventing colon cancer.
Cardiovascular risk and COX-2 inhibition in rheumatologic practice.
11] Moreover, it was recently demonstrated that acute BUO leads to marked upregulation of COX-2 in inner medulla; selective COX-2 inhibition prevents dysregulation of AQP2 in response to BUO, indicating that COX-2 may be an important factor contributing to the impaired renal water and sodium handling in response to BUO.
COX-2 inhibition results in increasing the activity of the lipoxygenase pathway and significant modulation of cytokine and NFkB-related gene expression.
The theory underlying the development of the coxibs was that selective COX-2 inhibition would provide analgesia and anti-inflammatory effects without the risks ofgastric bleeding associated with COX-1 inhibition.
The role of COX-2 inhibition in breast cancer treatment and prevention.
Five years ago, before COX-2 inhibitor drugs imploded in a mass of serious side effects, many herbal pain reliever products were claiming COX-2 inhibition.
Selective COX-2 inhibition reduces vascular prostacyclin synthesis without disrupting COX-1-derived thromboxane synthesis in platelets.