TARGET comprised 2 parallel substudies comparing the COX-2 selective inhibitor
lumiracoxib (not available in the United States) 400 mg daily with either ibuprofen 800 mg three times daily or naproxen 500 mg twice daily.
Our findings are in line with several previous studies which showed that treatment with COX-2 selective inhibitor
significantly improved cardiac function and reduced myocardial infarction size in different myocardial I/R animal models [12-15].
Last year's study of 336,906 community-dwelling Medicaid beneficiaries by the Veterans Affairs Tennessee Valley Healthcare System extended concerns about COX-2 selective inhibitors
to cerebrovascular disease, said Dr.
They found that there were significantly fewer upper gastrointestinal clinical events with the COX-2 selective inhibitor
etoricoxib than with the traditional NSAID diclofenac due to a decrease in uncomplicated events, but not in the more serious complicated events.
In those with a risk for GI bleeding, an NSAID in combination with misoprostol or a proton pump inhibitor or a COX-2 selective inhibitor
, such as celecoxib, rofecoxib, or valdecoxib, is appropriate.
Prevention of colorectal cancer through the use of COX-2 selective inhibitors
2) This disadvantage has been, to a limit, been overcome by the use of COX-2 selective inhibitors
Because the side effects of nonselective COX inhibitors are not uncommon, there is a tendency to use COX-2 selective inhibitors
, such as celecoxib, as an alternative pain control method.
Conventional or non-selective NSAIDs do inhibit both cox-1 and cox-2, while cox-2 selective inhibitors
inhibit only cox-2.
Justification for the Development of COX-2 Selective Inhibitors
The data suggest that "people who use low-dose aspirin for heart protection should take COX-2 selective inhibitors
rather than nonselective NSAIDs for treatment of arthritis and musculoskeletal pain," Dr.
for Arcoxia than for any other NSAID, including traditional NSAIDs and COX-2 selective inhibitors